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Pharmacological Targeting of Inflammasome Activation Mechanisms in Synuclein Models of Parkinson's Disease
… Our previous studies confirmed the activation of an immune system complex called the inflammasome is involved in … progression by blocking persistent activation of the immune system and chronic brain inflammation. Importance of This …
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Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson’s Disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity
July 6, 2020
… disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence that …
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Soluble CD163 changes indicate monocyte association with cognitive deficits in Parkinson’s disease
November 16, 2020
… with molecules associated with adaptive and innate immune system activation and with immune cell recruitment to the … and acute-phase proteins, suggesting a relation to chronic systemic inflammation. Our in vitro study showed that …
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Podcast: Parkinson’s Disease: What Else Goes Wrong?
February 5, 2014
… pressure control; constipation and problems with the GI system,” says Charles Adler , MD, PhD, professor of … Those symptoms are associated with the autonomic nervous system, the group of nerves responsible for involuntary …
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Intracellular Trafficking Dysfunction Caused by Alpha-synuclein Aggregation
… may place an excessive burden on the microtubule transport system, causing it to malfunction. We will also test whether … cargo protein of the microtubule transport system. Secondly, the role of a-synuclein aggregation in …
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Precision Mapping of Somato-Cognitive Action Network (SCAN) Pathophysiology in Parkinson’s Disease Gait Disturbance
… disorder caused by dysfunction in specific brain systems. We recently discovered a new brain system called the Somato-Cognitive Action Network (SCAN), …