… tract — influences the development of the nervous system, affects behavior and contributes to various disorders of the nervous system. Because non-genetic factors appear to play a role in …

… on alpha-synuclein folding. We are studying a simplified system in which sphingolipid can be maintained at more … sources could be undertaken using the current experimental system in order to identify compounds that would prevent …

… the brain stem as the first region in the central nervous system to be affected by alpha-synuclein aggregation. Since DMX is an integral part of the autonomic nervous system, it is postulated that damage to this brain region …

… alpha-synuclein and glucocerebrosidase in a range of cell systems including PD patient–derived cells. Furthermore, … drug discoverers through provision of a quantitative assay system which can been screened for new candidate drugs for …

… to find alternatives to the stimulation of the dopaminergic system through levodopa and dopamine agonists, as long-term … the glutamate receptor mGluR4, which bypasses the dopamine system, leads to functional improvement in pre-clinical …

… effectiveness as a PD treatment.   Study Design:  Using a system for growing bacteria, we will cultivate the L-dopa … viruses can trigger any systemic or local immune responses that could limit its …