… work focuses  organelle quality control by the ubiquitin system and autophagy. His recent work has led to the …

… efforts focused on Parkinson’s genetics, systems biology, and early-stage therapeutic discovery. …

… One session focused on therapies targeting the endolysosome system that handles the breakdown and recycling of materials in cells. This system is a growing area of interest for PD therapeutic … trigger cellular dysfunctions that impair the endolysosomal system and disrupt the clearance of alpha-synuclein. The …

… gene under the control of a doxycycline responsive turn-off system. This will give us an initial idea of whether this … Anticipated Outcome :  We have data that the regulated GDNF system works perfectly in prior pre-clinical models. … We believe we have demonstrated that our gene regulation system works well in a pre-clinical model. …

… understand how molecules move inside the central nervous system in order to target treatments to specific regions of … most parts of the brain and the rest of the circulatory system. While this barrier is critical for protecting the … messages pass between different areas within the nervous system) and even brain changes brought on by Parkinson’s …

… of the Neuronal Synuclein Disease Integrated Staging System (NDS-ISS) for better understanding of disease … how the Neuronal Synuclein Disease Integrated Staging System (NDS-ISS) can be used to stage participants in the … stages, emphasizing the need for further validation of this system. A better understanding of disease progression arcs …