… has been proposed that abnormalities in the enteric nervous system, a semi-independent network of nerves lining the … fluctuations), for modeling Parkinson’s in experimental systems (cells or animals), and for understanding the …

… degeneration of dopamine neurons in the central nervous system (CNS). It is now well established that PD lesions … to the biopsies of 10 control patients and 5 patients with multiple system atrophy (a parkinsonian syndrome which is a common …

… Objective/Rationale:  Researchers have previously demonstrated that the pattern and … evolution of progressive changes in the dopamine system in Parkinson’s disease (PD) associated with LRRK2 mutations are very similar to what is seen in non-inherited PD. We believe this will also be true for …

… diminished glutathione levels.  Cystine-glutamate exchange (system xc-) is a key regulator in the direct exchange of … drive the exchange of cystine-glutamate in recombinant cell systems.  We have also demonstrated that these molecules are …

… from 1974 to 2018 on 200+ pesticides. We will apply a systems biology approach with high-throughput data …