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Unraveling the Genetic Basis for Alpha-Synuclein Oligomerization in Living Cells Using Bimolecular Fluorescence Complementation
… cells. In our original project we set out to establish a system in which to visualize these smaller forms, which had … which influence the formation of asyn oligomers. Using the system we established in the initial funding period, we will …
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Development of MX-4565, a Novel Estrogen Analogue, for the Treatment of Parkinson's Disease
… from death in a number of cell culture and animal models systems. For example, it has been shown to provide complete … Outcome MIGENIX demonstrated good pharmacokinetics for systemic delivery of their estrogen analog drug MX-4565 in …
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Understanding the Molecular and Functional Changes of CB1/D2/A2A Receptor Complexes in the Hemi-parkinsonian Pre-clinical Model
… of modulation between the dopaminergic and cannabinoid system is direct interaction between CB1 cannabinoid and D2 … 6-OHDA-induced degeneration of the nigro-striatal dopamine system, a known model of PD. Project Description: …
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Targeting the JAK/STAT Pathway in the Treatment of Parkinson's Disease
… (PD) involves inappropriate activation of the immune system. Cytokines activate immune cells by engaging the … model is characterized by activation of the immune system at four weeks, with neurodegeneration with …
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A Breath of Relief: Inhaled Formulation of Levodopa Reduces ‘Off’ Periods in People with Parkinson’s
April 19, 2013
… faster; this is the nature of how the respiratory system works. It also helps that the drug bypasses the gastrointestinal system, where the food we eat can get in the way of our body …
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Make Your Voice Heard: Urge Congress to Support PD Research
August 9, 2016
… Diseases Act seeks to create a national data collection system for neurological diseases, including Parkinson’s, to … as other factors important to the research community. The system would provide a foundation for evaluating and …