… alpha-synuclein) via its effect on the Renin Angiotensin System in the brain, a system that is associated with cognition enhancement and … followed by other cellular and molecular analyses in multiple brain regions to understand how PNA5 alters …

… parkinsonisms (including progressive supranuclear palsy, multiple system atrophy and dementia with Lewy bodies), which account for …

… Disease . “We now understand Parkinson’s as a multisystemic disorder affecting all parts of the nervous system, … prognosis, but you mostly treat the alternate conditions [multiple system atrophy (MSA), progressive supranuclear palsy (PSP), etc.] …

… — to measure the amount and distribution of brain atrophy in both diseases, related to clinical severity. We …

… mechanism for LRRK2. This work will create a measurable system to detect the phosphorylation/ubiquitination of LRRK2 … cycle of LRRK2 modification. Project Goal: Cellular systems are ideal to study the molecular players in a … can be adapted to a multi-well format to enable testing of multiple regulators of LRRK2 phosphorylation at once. Study …

… addresses this need by developing a unique human cellular system for the early identification and study of … investigator plans to grow skin fibroblasts derived from multiple Parkinson’s patients and age-matched controls and …