… Rationale:  There is growing indication that the immune system plays a role in the development and progression of … the genes responsible for the regulation of the immune system, particularly HLA and KIR. The central element of … In some cases, the same variants show association with multiple traits, whereas in other cases, the associations …

… Parkinson’s in different ways.” Researchers believe that multiple systems are at work in cognitive dysfunction in PD, including the dopaminergic system known for its role in the motor symptoms of the …

… Objective/Rationale:  Multiple pieces of evidence converge on the notion that … model, and whether induction of this degradation system in vivo can be used to get rid of excess … in PD, is unknown. Project Description:  We will use a system of viral delivery, in which the gene of interest is …

… visualize alpha-synuclein in living human patients with multiple system atrophy (a related parkinsonism). AC Immune is now advancing …

… We aim to generate pre-clinical models that incorporate multiple genetic defects found in PD patients. In terms of … littermate controls. Characterization of the dopaminergic system and the neurobiological basis for this phenomenon is …

… the inflammatory response by modulating the immune system to alleviate the hostile environment associated with … to neuronal proteins and currently approved for use in multiple sclerosis, inhibit inflammation and neuronal death …