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Functional Analysis of LRRK2 Phosphorylation in Human Dopaminergic Neurodegeneration
… First, we will quantify LRRK2 phosphorylation at multiple sites on mDA neurons. mDA neurons with typical or … This project will lead to a better understanding of how multiple LRRK2 phosphorylation sites are regulated within …
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Allogeneic Bone marrow-derived Mesenchymal Stem Cells as a Disease-modifying Therapy for Idiopathic Parkinson’s Disease: Phase 2a Double-Blind, Randomized Controlled Trial
… neuroinflammation in PD. Hypothesis: We hypothesize that multiple intravenous infusions of mesenchymal stem cells … Next Steps for Development: This trial aims to prove that multiple infusions of mesenchymal stem cells are a safe and …
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Preclinical Efficacy and Biomarker Development for a Clinical Stage Inhibitor of Lipid Metabolism in Parkinson’s Disease
… that inhibits SCD. In this study, we will test YTX-7739 in multiple preclinical models that differ in how … reveal how YTX-7739 affects alpha-synuclein toxicity in multiple brain cell types and how people with PD may best …
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Evaluation of Digital Mobility Data to Identify Individuals at Risk of Developing Parkinson’s Disease
… technology provides accurate, sensitive assessment of multiple, disparate mobility functions, both in controlled … technology, which is capable of accurately capturing multiple mobility functions. Development of these …
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Ultra-sensitive Quantification of Phosphorylated LRRK2 in Biofluids from Clinical Trials of Therapeutic Candidates
… available. Hypothesis: We hypothesize that our novel “multiplexed” biomarker assay, which is designed to provide … new assay in measuring the activation of this pathway in multiple types of samples (including blood cells and … Following validation of our assay’s performance in multiple sample types, we expect that the assay will be …
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Kin Y. Mok, PhD, FRCP, MBBS
… and is a senior research associate. Dr Mok has published in multiple fields on the genetic basis of neurological …