… might transfer misfolded alpha-synuclein to the nervous system in disease. Hypothesis: We propose that gut microbes … pathological forms that might spread to the nervous system in a novel circuit important in PD.  Study Design: … (toxins and microorganisms) in two complementary model systems ( ex vivo cultures, and in vivo in mice) to …

… For the brain to work efficiently, its cells have systems to clear out old proteins that are no longer needed or functional. When these protein-clearing systems fail, old proteins accumulate and can interfere with … disorders such as Parkinson’s disease (PD). One of these systems involves tagging unusable or dysfunctional proteins …

… (CRL), he designs and coordinates studies on behalf of multiple clients to assess the efficacy of their molecules …

… in membrane biophysics research and has developed multiple single-vesicle assays to study SNARE-mediated …

… Division. Over the past 20 years, Dr. Schiess has led multiple trials for Parkinson’s disease (PD), including …

… Parkinson’s disease, neuromyelitis optica, lupus and multiple sclerosis. He continues to work in close …