… Grant: Myeloid cells (white blood cells) of the immune system include monocytes, neutrophils and dendritic cells found in circulation, as well as microglia (immune system cells) that reside within the central nervous system (CNS). Our original project focused on the role of …

… question with the typical lab approach because the immune system of models may differ a lot from a human’s immune system. We will overcome this limitation by using a unique model with a humanized immune system to test whether specific inflammatory changes in the …

… reducing inflammation in the peripheral and central nervous systems. The peripheral nervous system includes all of the nerves that branch out from the … including muscles and organs, while the central nervous system consists of the brain and spinal cord. We also …

… might transfer misfolded alpha-synuclein to the nervous system in disease. Hypothesis: We propose that gut microbes … pathological forms that might spread to the nervous system in a novel circuit important in PD.  Study Design: … (toxins and microorganisms) in two complementary model systems ( ex vivo cultures, and in vivo in mice) to …

… For the brain to work efficiently, its cells have systems to clear out old proteins that are no longer needed or functional. When these protein-clearing systems fail, old proteins accumulate and can interfere with … disorders such as Parkinson’s disease (PD). One of these systems involves tagging unusable or dysfunctional proteins …

… Dr. Murayama’s work included the recent publication of systemic distribution and propagation of Lewy body pathology in peripheral autonomic system including skin, adrenal gland and olfactory … radiological and pathological correlation of olfactory system for possible pre-clinical diagnosis. Dr. Murayama is …