The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018Functional Fine-mapping of LRRK2 Locus
Study Rationale:
Genetic studies for Parkinson's disease have indicated that variants of the LRRK2 gene are associated with increased risk of Parkinson's disease. However, we still know very little... -
Research Grant, 2018Optimization of Probe-ELISA Parkin Activity Assay
Promising Outcomes of Original Grant:
Certain forms of Parkinson's are due to defects in a cellular regulatory node known as the PINK1-Parkin pathway. With previous funding from MJFF, we sought to... -
Research Grant, 2018Evaluating the Therapeutic Potential of the Systemic Antagonism of Dopamine Receptor D3
Promising Outcomes of Original Grant:
Parkinson's disease involves toxic forms of certain proteins (e.g., alpha-synuclein) in the brain, which trigger an immune response driven by inflammatory... -
Research Grant, 2018Structure-Based Design of Small-Molecule Activators of Parkin
Promising Outcomes of Original Grant:
The protein Parkin requires activation by another enzyme called PINK1. With previous MJFF funding, we identified a new class of chemical fragments that could be... -
LRRK2 Biology Consortium, 2018LRRK2 Inhibitors for the Treatment of Gastrointestinal Symptoms of Parkinson’s Disease
Study Rationale:
Parkinson's disease (PD) affects nearly any body system, as evidenced by the diversity of its symptoms. While its non-motor symptoms, such as olfactory dysfunction, rapid eye movement... -
Research Grant, 2018Searching Brain Scan Data for Patterns of Activity Associated with Parkinson's Disease
Study Rationale:
There is a pressing need for Parkinson's disease (PD) biomarkers -- objective measures of disease -- that will enable early and accurate diagnosis and allow to track disease...
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Our funding programs support basic, translational and clinical research from academia and industry.