The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Community Fast Track, 2005Role of corticostriatal neurons in provoking the imbalance between the direct and indirect striatal output pathways after dopamingergic degeration
The striatum receives massive excitatory inputs from the cortex and is densely innervated by dopamine. Striatal projection neurons belong either to the direct or indirect pathways. Models of Parkinson...
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Community Fast Track, 2005Pathogenesis of PD in alpha-synuclein cleavage by matrix metalloproteinase-3
A recent finding from our research strongly indicates that matrix metalloproteinase-3 (MMP-3), a protein-cleaving enzyme, plays a pivotal role in degeneration of dopamine neurons in models of...
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Community Fast Track, 2005Park8 Pre-clinical Models and LRRK2 Kinase Substrates
LRRK2 is the most recent gene linked to PD and mutations in the gene represent one of the most common genetic causes of PD identified to date. However, little is known about the function of the LRRK2...
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Community Fast Track, 2005Guidance of Midbrain Dopaminergic Neurons in Development and Disease
A promising approach to alleviating the symptoms of Parkinson's disease is to transplant healthy dopaminergic neurons into the brains of these patients. Due to the large number of dopaminergic neurons...
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Community Fast Track, 2005Specific Inhibition of Nucleation of Alpha-synuclein Aggregation As a Therapeutic Strategy
The pathological hallmark of Parkinson's disease is the accumulation in nerve cells of dense clumps of aggregated protein. The clumps, called Lewy bodies, contain mostly a protein called alpha...
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Community Fast Track, 2005K-ATP Channels and Their Role in the Survival of Nigral Dopaminergic Neurons
ATP-sensitive potassium (K-ATP) channels are present is numerous tissues including the brain. Their function has been best studied in the pancreatic B-islet cells that participate in the regulation of...
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Our funding programs support basic, translational and clinical research from academia and industry.