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Funded Studies

Jean-François Trempe, PhD

Assistant Professor at McGill University, Department of Pharmacology and Therapeutics

Location: Montreal, Quebec Canada

Jean-François Trempe, PhD, obtained his doctoral degree from the University of Oxford in 2007. He pursued postdoctoral training at McGill University and the Montreal Neurological Institute, Canada, and became an assistant professor at McGill University in 2013. Dr. Trempe studies the structure of proteins that play a role in Parkinson's disease and aims to describe the function of these proteins. He currently holds a Canada Research Chair in Structural Pharmacology associated with a Canadian Fund for Innovation (CFI) grant. He received the New Investigator Award from Parkinson Society Canada in 2014. He has published 40 articles during his career, notably on the topics of ubiquitin and neurodegenerative diseases. His most important contributions to date are the structure determination of Parkin, published in Science in 2013, which revealed the mechanism of inhibition of this important target, and the mechanism of ubiquitin recognition by PINK1 through autophosphorylation (Rasool et al EMBO Rep 2018). 


Associated Grants

  • Structure-Based Design of Small-Molecule Activators of Parkin

    2018


  • Making Changes in the Parkin Gene to Activate the Protein Parkin

    2017


  • Structure-based Design of Pharmacological Activators of Parkin

    2013


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