The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
LRRK2 Challenge, 2013Direct Activity Sensor for Interrogating LRRK2 in Complex Biological Samples
Objective/Rationale:
Mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) that increase the kinase’s activity – transferring groups of chemicals called phosphates – have been associated with... -
Research Grant, 2013LRRK2 Phosphatases Confirmation
Promising Outcomes of Original Grant:
The molecular events that precipitate the onset of Parkinson’s disease (PD) have yet to be precisely defined; however current research indicates that the Leucine... -
Dyskinesia Challenge, 2013Deciphering the Role of Histone Deacetylase in Levodopa-Induced Dyskinesia
Objective/Rationale:
It is well known that repeated administration of levodopa causes gradual changes in striatal gene expression that eventually result in the development of levodopa-induced... -
Rapid Response Innovation Awards, 2013Alpha-synuclein Picobody: A Novel Blood-Brain Barrier Permeable Diagnostic Ligand for Parkinson's Disease
Objective/Rationale:
The presence of the blood-brain barrier (BBB) has been an insurmountable impediment to successful drug delivery to the central nervous system. To circumvent the BBB... -
Dyskinesia Challenge, 2013Imaging Dyskinesia in People with Parkinson's Disease
Objective/Rationale:
Levodopa-induced dyskinesias are abnormal involuntary movements that may develop with levodopa therapy for Parkinson's disease (PD). Recent studies on pre-clinical... -
LRRK2 Pharmacodynamic Assays, 2013LRRK2-associated Mitochondrial DNA Damage as a Phenotype for Unbiased Screening
Objective/Rationale:
The normal functions of LRRK2 are poorly understood, and the mechanism(s) by which LRRK2 mutations cause PD are unclear. Also, therapeutic development has been hampered by the...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.