The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Understanding LRRK2 Biology, 2009Identification of LRRK2 Substrates in Pre-clinical Models of Parkinson's Disease
Objective/Rationale:
Mutations in the LRRK2 gene are a common cause of familial and sporadic Parkinson’s disease. The LRRK2 protein can function as a kinase in vitro and certain familial mutations may... -
Understanding LRRK2 Biology, 2009Functional Analysis of LRRK2
Objective/Rationale:
LRRK2 is a gene that, when not working properly, causes Parkinson’s disease. However, the function of this large gene and its involvement in the disease process is virtually... -
Understanding LRRK2 Biology, 2009Development of Biochemical Assays for LRRK1
Objective/Rationale:
Studies over the last several years have identified the protein kinase LRRK2 as a potential target for Parkinson’s disease therapeutics. While targeting kinases has been a... -
Biomarkers, 2009T-Cell Receptors Changes as a Biomarker of Parkinson's Disease
Objective/Rationale:
The diagnosis of PD is based on clinical characteristics because there are no reliable blood tests for early diagnosis or to follow the progressive course of the disease. Along... -
Rapid Response Innovation Awards, 2010Generation of a Novel Recombinant Protein Activator of GPR88
Objective/Rationale:
Dopamine replacement therapy activates neurons in a particular region of the brain, the striatum, leading to an improvement in disease symptoms. This action occurs through a... -
Rapid Response Innovation Awards, 2010Circulating microRNAs as Biomarkers for Early Detection of Parkinson's Disease
Objective/Rationale:
MicroRNAs (miRNAs) are small, conserved RNAs that interact with target sequences on messenger RNAs. MiRNAs have been proven to regulate the expression of many genes and play...
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Our funding programs support basic, translational and clinical research from academia and industry.