The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Priority Biology, 2021Efficacy of PRKN Gene Delivery toward Mitigation of Alpha-synuclein-induced Degeneration
Study Rationale:
Genetic mutations that cause the functional loss of the PRKN gene and its corresponding protein, parkin, can cause early-onset Parkinson’s disease (PD). Regardless of the cause... -
Target Advancement Program, 2021Exploring the Role of FAIM, an Inhibitor of Cell Death, in Parkinson’s Disease
Study Rationale:
Parkinson’s disease (PD) is characterized by the degeneration of dopamine-producing neurons in the brain. We recently discovered that a protein called FAIM can protect neurons from... -
Target Advancement Program, 2021SCARB2 as a Potential Target in Parkinson’s Disease
Study Rationale:
Mutations in GBA, a gene that encodes an enzyme called glucocerebrosidase, are a common risk factor for Parkinson’s disease (PD). Inside cells, glucocerebrosidase must be escorted to... -
Priority Biology, 2021Studying the Properties of Alpha-Synuclein Aggregates Amplified from Human Cerebrospinal Fluid
Study Rationale:
Aggregates of the protein alpha-synuclein, which accumulate in the brains of people with Parkinson’s disease (PD), can also be detected in biofluids like cerebrospinal fluid (CSF)... -
Research Grant, 2021Comparing the Effectiveness of Two Imaging Methods for Monitoring the Progression of Parkinson’s Disease
Study Rationale:
Parkinson’s disease robs the brain of dopamine, a neurochemical needed for normal movement and cognition. A variety of imaging methods can be used to monitor the brain’s dopamine... -
Therapeutic Pipeline Program, 2021Evaluation of a Drug that Removes Excess Iron from the Brain as a Treatment for Parkinson’s Disease
Study Rationale:
In Parkinson’s disease (PD), the death of cells in brain regions that control movement causes motor symptoms. Brain imaging studies show that iron builds up in these areas, damaging...
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Our funding programs support basic, translational and clinical research from academia and industry.