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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022
    Therapeutic Efficacy of IC 100 in Small Models

    Study Rationale: Parkinson’s disease (PD) is characterized by the loss of neurons in the brain. Despite available treatments, no approved therapy can slow disease progression. Data in humans and small...

  • Fall 2021 RFP: Outcome Measures, 2022
    Pet Imaging to Determine Regional and Temporal Trajectories of Reactive Astrocytosis in Parkinson’s Disease

    Study Rationale: Neuroinflammation is a known process accompanying Parkinson’s disease (PD) neuropathology. During this process, specific brain cell populations become chronically activated, including...

  • Fall 2021 RFP: Outcome Measures, 2022
    LRRK2 Kinase Activity and Global Proteomic Biomarkers in the Gut of Patients with Parkinson’s and/or Inflammatory Bowl Disease

    Study Rationale: Accumulative evidence suggests a strong connection between the brain and the gut, with chronic intestinal inflammation being linked to an increased risk of Parkinson’s disease (PD)...

  • Spring 2022 RFP: Expanding Biological Understanding of Parkinson's Disease, 2022
    The Role of Acid Ceramidase in GBA1 in Parkinson’s Disease

    Study Rationale: Mutations in the GBA1 gene are one of the most common risk factor for Parkinson’s disease (PD). GBA1 encodes glucocerebrosidase, an enzyme that breaks down a lipid called...

  • Research Grant, 2022
    Undiagnosed Parkinson’s in the Emergency Department: An Opportunity for Early Intervention

    Study Rationale: Many patients diagnosed with Parkinson’s disease had signs or symptoms of the disease years before an actual diagnosis is made. An astonishingly high percentage of these patients are...

  • Winter 2021 RFA: Alpha-synuclein Seed Amplification Assay Program, 2022
    Digital Detection of Alpha-synuclein Aggregates for the Quantitative Diagnosis of Parkinson’s disease

    Study Rationale: The detection of protein aggregates is currently at the leading edge of diagnostic developments in Parkinson’s disease and other age-related disorders. There is demand for...

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