The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
Translational Pipeline Program, 2023Using Sleep Modulation to Enhance the Brain’s Waste Clearance Mechanisms as an Approach to Limiting the Progression of Parkinson’s Disease
Study Rationale: Recent studies have demonstrated that the brains of people with Parkinson’s disease (PD) show a buildup of toxic proteins that is due to an impairment in the brain’s waste clearance...
Accelerating the Translation of Parkinson's Disease Therapies, 2023Evaluating Polyamines as Biomarkers for Parkinson’s Disease
Study Rationale: One of genes associated with Parkinson’s disease (PD), ATP13A2, regulates the levels of polyamines in the lysosome, an acidic compartment of the cell. Polyamines are neuroprotective...
Biomarkers to Support Therapeutic Trials Program, 2023Developing a novel platform for patient selection and disease tracking using super-resolution microscopy and AI
Study Rationale: The ability to track alpha-synuclein pathology in tissues outside the brain would facilitate accurate diagnosis of Parkinson's disease (PD), enable inclusion of individuals with alpha...
Translational Pipeline Program, 2023Exploring the Use of Molecules that Stabilize the Interaction between LRRK2 Kinase and the 14-3-3 Adapter Protein as a Neuroprotective Therapy for Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) is associated with activating mutations in a protein kinase called LRRK2. In previous studies, we found that regulating LRRK2’s chemical modification by...
Research Grant, 2023A Novel Preclinical Candidate for Reducing Alpha-synuclein Aggregation in Parkinson’s Disease
Study Rationale: The goal of this program is to develop a novel drug for Parkinson’s disease (PD) with a unique mechanism of action. We have a drug candidate that shows potential as an inhibitor of...
Research Resources Imaging Program, 2023Development of Biomarkers Based on Brainstem Nuclei for Prodromal Parkinson's Disease
Study Rationale: Early diagnosis of Parkinson’s disease (PD) requires development of biomarkers that can be used to detect the first signs of neurodegeneration. Animal models suggest that tiny regions...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.