… original grant was to utilize pre-clinical and human model systems to better understand LRRK biology. The original aims … LRRK2 KO model with respect to the dopaminergic system and 3) create human lines containing PD associated … the role of autophagy in basic LRRK2 biology, in the immune system, and in mitochondrial quality control. Importance of …

… to alter a particular location in the genome. The CRISPR system penetrates the cells through a safe delivery system and will only change the expression of the SNCA gene … study will optimize delivery and the design of the CRISPR system in pre-clinical models of tParkinson’s disease and …

… all cell types in our body. We have established a culture system to induce human ES cells to give rise to precursors … of brain and spinal cord cells. We will create a culture system that allows the neural precursors to generate … dopamine neurons. This way, we will optimize the culture system to generate maximal number of transplantable dopamine …

… sites for diagnosing PD, test current pathological staging systems for PD and survey the spinal cord and peripheral nervous system for the distribution of Lewy body-related pathology. … in PD, publication of an improved pathological staging system for PD and the first detailed mapping of Lewy …

… to understanding alpha-synuclein biology using model systems ranging from yeast to human stem cells, advancing … disease (PD).  His group developed experimental and systems biology approaches to stratify patients with …

… Anne Weissbach is a clinician-scientist at the Institute of Systems Motor Science and the Institute of Neurogenetics at … at the University of Toronto, Canada and the Institute of Systems Motor Science of Alexander Münchau at the UKSH …