… humans and in research models support a role for the immune system in the progression of Parkinson’s disease. Local … bring understanding to how the peripheral adaptive immune system (T cells) interacts with the brain resident immune system (microglia), and that this knowledge will permit us …

… handful of candidate enzymes in a lower organism worm based system. These gains will now be channeled into a rodent … In other words, hits from a high throughput screening system in worms will now be applied in a rational manner to … and dopamine neuron loss. The chosen factors will be systematically tested in rats to block dopamine …

… and fewer and fewer dopamine terminals survive, another system kicks in: the seratonin neurons. The serotonin … dopamine in a physiological manner. The seratonin system is known to be affected in PD, but the extent of … innervation in the synthesis and release of dopamine from systemically administered levodopa and in the development of …

… the organization and function of the mammalian nervous system. He has made fundamental contributions to our … methods to bridge the gaps between molecular, cellular and systems neuroscience. …

… Associate Director for Research at VA Ann Arbor Health System Geriatrics Research, Education, and Clinical Center, … imaging methods to understand the changes in neurochemical systems driving these important features of Parkinson’s …

… T and B cell-mediated immune responses in mucosal versus systemic tissues. Comparative investigation of inflammation in the intestine and the central nervous system is our favorite research topic. Utilizing various …