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Image-Guided Convective Delivery of AAV Vectors
… by utilizing the clinically appropriate frameless guiding system in order to translate these experiments into a …
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Identification of Substrates and Development of a Cell Based Assay for LRRK2
… based treatments. Project Description: We have developed a system of studying the LRRK2 enzyme in the lab and will use …
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Regulation of LRRK2 Activity by Nitric Oxide-Mediated Protein S-Nitrosylation
… mechanisms that regulate LRRK2 activity in relevant model systems. LRRK2 has been implicated as a major cause of PD …
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Validation of ATP13a2 / PARK9 as a Target to Reduce Neurodegeneration Induced by Alpha-Synuclein
… suppresses alpha-synuclein’s toxicity in model systems, making it a strong potential target for PD …
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Alpha-synuclein and Tau Mislocalization to Dendritic Spines
… spines. Project Description: We will use our live imaging system to investigate how accumulation of alpha-synuclein …
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Validation of Lysosomal Enzymes Assay in CSF - One-year Extension of the RRIA: CSF Lysosomal Hydrolases' Activity as Possible Marker of Parkinson's Disease
… via a lysosomal degradation pathway and the lysosomal system is altered in PD, we hypothesized that measurement of … the reliability of our results, we will carry out a systematic series of experiments aimed at controlling for …
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