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Development of Nanobodies as Novel Tools to Characterize LRRK2 as a Potential Drug Target for Parkinson's Disease
… (accelerates chemical reactions) functions. Targeting the multiple enzymatic functions of LRRK2 represents a very … fragments derived from a special type of antibodies (immune system cells) present in camelids such as llamas. In recent …
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Therapeutic Development of Novel STING Inhibitors to Treat Parkinson's Disease Neuroinflammation
… We will also conduct IND-enabling toxicology studies in multiple preclinical models. Impact on Diagnosis/Treatment … toxicology studies, we will complete a full assessment of systemic and CNS metrics. We also plan to engage interested …
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Staff on the Move: Foundation’s Unique Role in Venture Philanthropy
October 7, 2013
… Venture Support.’ Karen Chen, PhD, from the Spinal Muscular Atrophy Foundation also will speak on the foundation role; …
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Alberto Ascherio, MD, DrPH
… Alberto Ascherio leads multiple NIH-funded projects involving both national and … Ascherio has developed the skills to efficiently manage the multiple steps of scientific research, from study design and … the past 25 years, he has direction the investigations of multiple sclerosis (MS), Parkinson’s disease (PD) and …
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Pharmacological Testing of Nurr1 Agonists in Pre-clinical Models of Parkinson's Disease
… Björklund (Sweden). The Isacson laboratory will use a “multiple hit” model in which DA neuronal loss in the … of human wild type alpha-synuclein in the nigrostriatal system induces progressive loss of DA neurons that … degeneration in two preclinical models of PD based on a “multiple hit” pre-clinical model of inflammation and …
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Measuring Parkinson’s Protein throughout Body
March 16, 2016
… Today, The Michael J. Fox Foundation (MJFF) launched the Systemic Synuclein Sampling Study (S4) to further … research at the Institute for Neurodegenerative Disorders. “Multiple studies have demonstrated the significance of … biomarker, but none have measured alpha-synuclein levels in multiple biofluids and peripheral tissues in a single …