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Determining the Level of LRRK2 Inhibition Required for Therapeutic Efficacy
… has yet to be determined. This study will examine multiple levels of target engagement in a model of … linked to LRRK2 inhibition). Next, we will determine multiple doses of PFE360 that produce differing levels of …
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Kevin J. Tomaselli, PhD
… first-in-class, oral small molecule currently in multiple Phase 2 clinical trials in hematologic and solid … focused on apoptosis, or programmed cell death, across multiple therapeutic areas, including cancer, CNS, …
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Carole Ho
… tenure at Genentech, she led the successful development of multiple therapeutics that advanced to Phase III trials or were approved, including ocrelizumab for multiple sclerosis, lampalizumab for age-related macular …
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Share Your Story
… that apply) Dementia Other neurological conditions (like multiple sclerosis and multiple system atrophy) Cardiovascular disease (like hypertension and …
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Sex-Related Longitudinal Change of Motor, Non-Motor, and Biological Features in Early Parkinson's Disease
January 21, 2022
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Jon Palfreman Reports on “Brain Strains”
July 23, 2013
… cause disease. He cites a recent paper that suggests that multiple strains of potentially disease-causing altered … the disease in so many different ways. In short: multiple strains of multiple altered proteins might be working together in …