The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2025Identifying Protein Changes Associated with Parkinson’s Disease: Proteomics Public Data Compilation
Study Rationale: Accumulation of toxic protein aggregates is a hallmark of neurodegenerative disorders that include Parkinson’s disease (PD), Lewy body dementia (LBD) and multiple system atrophy (MSA)...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biomarkers, 2025Development of an Assay for Rapid Detection of Activated LRRK2
Study Rationale: Mutations associated with Parkinson’s disease (PD) elevate the activity of a protein called Leucine-rich repeat kinase 2 (LRRK2). Kinases add phosphate groups to other proteins and to...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024First-in-human Phase 1a Study to Assess Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending doses of SB-0110 after Oral Administration in Healthy Subjects
Study Rationale: Although levodopa is an effective treatment for Parkinson’s disease (PD), it has a debilitating on-target side effect of dyskinesia. An optimal PD therapy would selectively activate...
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iPSC Phenotyping Environmental Exposure Program, 2025Assessing How Triplication of the Alpha-synuclein Gene Affects Electrophysiological and Mitochondrial Phenotypes in Neurons, Astrocytes and Microglia
Study Rationale: One common familial inherited form of Parkinson’s disease (PD) is caused by triplication of SNCA, the gene that encodes the protein alpha-synuclein. Alpha-synuclein forms toxic...
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Research Grant, 2024Determining Optimal Cognitive Measures and Clinical Trial Endpoints in Lewy Body Disorders
Study Rationale: People with Lewy body disorders, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), often experience cognitive impairment that can impact function, independence...
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, 2024Epigenetic Analysis of Peripheral Immunity in Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) has increasingly been linked to dysfunction in the immune system, with evidence showing abnormal activity in blood immune cells and their potential role in...
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Our funding programs support basic, translational and clinical research from academia and industry.