MJFF recognizes the need for standardizing the characterization of PD pre-clinical models. The currently available pre-clinical models have been characterized at several academic laboratories, however, results have been difficult to compare due to varying methodologies.
MJFF began concerted efforts to strengthen the understanding of model features by taking on responsibility for model comparisons with the goal of generating a minimal set of data on new and existing models. Newly generated and currently available pre-clinical models will undergo behavioral, biochemical, immunohistological and stereological analyses at three different ages. These experiments will be performed by independent CRO’s to create a set of uniformed and streamlined characterization data, and this phase 2 phenotypic data will be shared with the PD research community on PD Online Research website.
Relevance to Diagnosis/Treatment of Parkinson’s Disease:
The minimal set of data on phenotypic characterization on new and existing models will allow investigators to make decisions for best model to use for a particular hypothesis.
Uniform phenotypic characterization data on PD pre-clinical models