To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Mfn2 LoxP Floxed Mouse*
Mouse Model
Mice with LoxP sites flanking Mfn2 exon 6. Model was generated and deposited by David Chan at California Institute of Technology through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:026525
Human Parkin Mouse*
Mouse Model
Transgenic mice expressing wild type human Parkin under the direction of the mouse prion protein promoter. Model was generated and deposited by Konstanze Winklhofer at Ruhr University Bochum through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:027630
Alpha-Synuclein Knockout Mouse*
Mouse Model
SCNA knockout mice carrying a 1164 bp fragment deletion in exon 2. Model was generated and deposited by Vladimir Buchman at Cardiff University School of Biosciences through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:028559
ROSA SNCA Knockout Mouse*
Mouse Model
Mice carrying SNCA knockout allele and Gt(ROSA)26Sor Cre reporter allele. Model was generated and deposited by Vladimir Buchman at Cardiff University School of Biosciences through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:028560
LRRK2 S910A/S935A Knockin Mouse*
Mouse Model
Mice carrying LRRK2 S910A and S935A mutations in exon 21. Model was generated and deposited by Dario Alessi at University of Dundee through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:028801
ROSA LRRK2 R1441C Mouse*
Mouse Model
Transgenic mice with human LRRK2 R1441C inserted into the endogenous Gt(ROSA)26Sor locus. Model was generated and deposited by Darren Moore at Van Andel Research Institute through the MJFF Sponsored Tools Program (available through cryorecovery).
LRRK2 Antibody (8G10)
Antibody
Mouse monoclonal antibody directed against wild-type LRRK2 using a fragment of LRRK2 (AA 100-500)
RILPL1 Antibody
Antibody
Mouse monoclonal antibody directed against total rodent/human RILPL1 protein. Suitable for immunoblot, immunoprecipitation, and immunocytochemistry experiments. This antibody is a chimeric mouse IgG2a version of the rabbit anti-RILPL1 antibody (MJF-R41-21, ab302492).
Rab 8A Antibody
Antibody
Mouse anti-Rab8A antibody that has undergone Fc species switching to develop mouse reagents from the original rabbit antibody (MJF-R22-79-3). The new chimeric antibody is approved for immunoblotting, immunoprecipitation, immunostaining, and flow cytometry and can be detected using Fc-specific secondary antibodies to mouse IgG.
AAV Mouse SNCA 3xmiR/GFP Plasmid
DNA Plasmids
Viral transgene plasmid used in the AAV Mouse SNCA 3xmiR/GFP viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit groups only. RRID:Addgene_194248
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic