To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
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AAV1/2-CAG-Human SNCA 3xmiR/GFP
Viral Vector
CNS optimized viral vector (AAV1/2 pseudotype) encoding GFP and 3XmiR to alpha-synuclein for specific knockdown of WT human a-syn and common pathogenic mutant forms (A53T, A30P, E46K). Scrambled Control 3xSCRmiR/GFP available as a control in Reporter section and AAV Human SNCA 3xmiR/GFP plasmid available in the Plasmid section.
Generated as part of the Industry Tools Consortium.
HdAd5 3xFLAG-TK
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged TK. For use as a control with the HdAd5 3xFLAG-LRRK2 (WT, G2019S, G2385R) viral vectors.
AAV2/5-CBh-Alpha-Synuclein
Viral Vector
Viral Vector (AAV2/5 serotype) encoding wild-type human alpha-synuclein. AAV2/5-CBh-empty vector control is available as a control (listed in the Control gene/protein type section) and the AAV-CBh-alpha-synuclein plasmid is available in the Plasmid section.
Total Rab 8 Antibody
Antibody
Mouse monoclonal antibody directed against the human total Rab 8 protein. Suitable for immunoblot and immunostaining experiments. Epitope was mapped to amino acids 101-108.
Rab8 pS111 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine111 of the human Rab8 protein (PINK1-related phosphorylation event). Suitable for immunoblot and immunocytochemistry experiments.
AAV2/5-CBh-eBFP
Viral Vector
Viral Vector (AAV2/5 serotype) encoding eBFP to be used as a control for the AAv2/5 WT Human alpha-synuclein viral vector. This virus will not be made available as the QC/QA testing shows that it induces undesired inflammation and toxicity. Since stocks are available, groups may send a request for samples to tools@michaeljfox.org and may be granted access after vetting.
LRRK2 Antibody (N241A/34)
Antibody
Mouse monoclonal antibody directed against wild-type LRRK2 using a fragment of LRRK2 (AA 970-2527).
Rab 8 pT72 Phosphospecific Antibody (Non-Selective)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine72 of the human Rab 8 protein. Suitable for immunoblot and immunoprecipitation experiments. Note: Cross reacts with threonine-phosphorylated Rabs 3, 10, 35, and 43.
Rab 10 pT73 Phosphospecific Antibody (IP/WB)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine73 of the Rab 10 protein. Recommended for immunoblot and immunoprecipitation. A separate antibody (ab241060) is available for immunostaining.
Rab 29 pT71 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine71 of the human Rab 29 protein. Suitable for immunoblot experiments.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic