To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
-
Sponsored Tools Program
Learn more about how MJFF can help share your tools.
-
Tools Consortium
MJFF is working with industry to develop priority tools.
-
Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
Filters
HdAd5 3xFLAG-LRRK2 (G2385R)
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged LRRK2 with the G2385R mutation. HdAd5 FLAG-TK available as a control in Control section.
Full Length pS129 Alpha-Synuclein Protein
Protein
Phospho-S129 Alpha Synuclein semi-synthetic phosphomimetic protein generated by native chemical ligation of a recombinant peptide produced from E. coli and a synthtic peptide
DJ-1 proteins (recombinant proteins generated using an E. Coli expression system)
Protein
The following versions of recombinant DJ-1 protein generated using an E. coli expression system are available:
- Untagged DJ-1
- His-tagged DJ-1
- Oxidized DJ-1
DJ-1 proteins (recombinant proteins generated in a mammalian-optimized expression system)
Protein
The following versions of recombinant DJ-1 protein generated using a mammalian-optimized expression system are available:
- His-tagged DJ-1
- TEV-cleaved DJ-1
LRRK1 KO Rat*
Rat Model
Knockout of the gene encoding LRRK1 in the Long Evans Hooded rat strain. RRID:RGD_7241057
LRRK2 pS973 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine 973 of LRRK2.
PINK1 KO Rat*
Rat Model
Homozygous rat knockout of Pink1 (PTEN-induced putative kinase 1) in the Long Evans Hooded rat strain. RRID:RGD_7241054
LRRK1/2 Double KO Rat*
Rat Model
Double knockout of the genes encoding LRRK1 and LRRK2 in the Long Evans Hooded rat strain. RRID:RGD_7241053
LRRK2 Antibody (MJFF4)
Antibody
Rabbit monoclonal antibody directed against wild-type LRRK2. The antibody was mapped to the LRR domain of LRRK2 (AA 1035-1239).
AAV1/2-CAG-Mouse SNCA 3xmiR/GFP
Viral Vector
CNS optimized viral vector (AAV1/2 pseudotype) encoding GFP and 3XmiR to alpha-synuclein for specific knockdown of WT mouse a-syn and common pathogenic mutant forms (A53T, A30P, E46K). Scrambled Control 3xSCRmiR/GFP available as a control in Reporter section and AAV Mouse SNCA 3xmiR/GFP plasmid available in the Plasmid section.
Generated as part of the Industry Tools Consortium.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic