To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
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* = MJFF does not control pricing or terms of availability for this tool.
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Total Rab 10 Antibody
Antibody
Rabbit monoclonal antibody directed against the total Rab 10 protein. Suitable for immunoblot, immunoprecipitation, immunofluorescent staining, and flow cytometry experiments. This antibody epitope was mapped to C-terminus amino acids 185-193.
Ubiquitin pS65 Phosphospecific Antibody (WB/ICC/ELISA)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine65 of ubiquitin. Suitable for immunoblot, immunocytochemistry, and ELISA applications. Detailed characterization data is published in Watzlawik et al, Autophagy 2024.
Total DJ-1 Antibody
Antibody
Mouse monoclonal antibody directed against full length DJ-1. Ideal for use in immunoblotting or immunoassays.
Alpha-Synuclein Aggregation Assay*
Assay
High-throughput in vitro assay to detect alpha-synuclein aggregation developed in a dopamine neuron-like cell line of human origin. Available as a fee-for-service assay.
Generated as part of the Industry Tools Consortium.
LRRK2 G2019S KI Mouse
Mouse Model
Mice expressing the human G2019S point mutation introduced into exon 41 of the mouse LRRK2 gene.
LRRK2 Antibody (SIG-39840)
Antibody
Mouse monoclonal antibody generated in a mouse lacking endogenous LRRK2 protein using a peptide of LRRK2 (AA 2069-2087).
Rab 12 pS106 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine106 of the human Rab 12 protein. Suitable for immunoblot experiments.
GBA D409V Knockin x Thy1-Alpha-Synuclein Mouse
Mouse Model
Transgenic mice resulting from the cross between transgenic mice overexpressing the D409V mutant form of GBA (homozygous) and transgenic mice overexpressing wild type human alpha-synuclein directed by the murine Thy-1 promoter (hemizygous).
Generated as part of the Industry Tools Consortium. RRID:IMSR_JAX:029124
Parkin W402A KI Mouse
Mouse Model
CRISPR/Cas9 generated mice carrying the Park2, Parkinson disease (autosomal recessive, juvenile) 2, parkin, W402A point mutation in exon 11.
Generated as part of the Industry Tools Consortium. RRID:IMSR_JAX:029317
Rat Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-length rat alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. Please note: Validation of the rat alpha-synuclein monomers for making pre-formed fibrils identified a lack of pathology in vitro in mouse primary hippocampal neurons and in vivo in rat. Email tools@michaeljfox.org with questions or for more information.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic