To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson’s disease research.
Find a Research Tool
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GPNMB Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in GPNMB, including heterozygous and homozygous knockout.
These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
ATP13A2 Antibody (Ms - WB, IHC, ICC, IP)
Antibody
Rabbit monoclonal antibody directed against mouse ATP13A2 for for immunoblotting, immunostaining, and immunoprecipitation applications. The epitope of this antibody was mapped to AA1029-1036.
This antibody development project is part of the Aligning Science Across Parkinson’s (ASAP) Initiative.
GBA1LP Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered homozygous knockout of GBA1LP.
These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
Estimated Availability: Late 2025
SYNJ1 Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in CTSB for heterozygous and homozygous R219Q mutations.
These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
Conditional LRRK2 R1441G KI Mouse*
Mouse Model
Mice designed for conditional knockin of the LRRK2 R1441G mutation. Model was generated and deposited by Dr Dario Alessi at the University of Dundee through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
MHC-I H2-Kb Antibody
Antibody
Rabbit monoclonal antibody directed against mouse MHC-I H2-Kb for immunoblotting and immunostaining applications. This antibody cross-reacts with K-B, K-K, K-Q, KW-28, D-D, alpha chain, D-K and H2-Q8.
This antibody development project is part of the Aligning Science Across Parkinson’s (ASAP) Initiative.
DJ-1 Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in PARK7 (DJ-1), including:
- -D194A (heterozygous and homozygous)
- -L166P(heterozygous and homozygous)
These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
ITSN1 Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in ITSN1, including:
- - Knockout (homozygous)
- - R992* (heterozygous and homozygous) - in development, est Q3 2026
These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
LRRK2/GBA Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered LRRK2 G2019S (heterozygous and homozygous) and GBA1 N370S (heterozygous and homozygous).
These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
Anticipated Availability: Q4 2026
Anxa1-Cre Mouse*
Mouse Model
Anxa1-Cre knock-in mice express Cre recombinase from the mouse Anxa1 promoter in Anxa1-expressing cells and subtypes of dopaminergic neurons. Model was generated and deposited by Dr. Rui Costa at Allen Institute through the MJFF Sponsored Tools Program, and supported by the Aligning Science Across Parkinson’s (ASAP) Initiative.
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"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic