To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
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PRKN Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in PRKN, including heterozygous and homozygous R275W, T240M, R42P, and P437L mutations. These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by Aligning Science Across Parkinson's (ASAP).
Alpha-Synuclein pS129 Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine 129 of alpha-synuclein.
SNCA Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in SNCA, including heterozygous and homozygous A53T, A30P, E46K, and R219Q mutations. These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by Aligning Science Across Parkinson's (ASAP).
USP30 Knockout A549 Cell Line
Immortalized Cell
A549 cell with homozygous knockout of USP30.
Oxidized-DJ-1-Specific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against oxidized DJ-1 protein.
LRRK2 Wild-type Mouse
Mouse Model
Mice express a wild-type human LRRK2 gene directed by its endogenous promoter/enhancer regions on the BAC transgene. The human LRRK2 protein expression is approximately 5-fold over endogenous mouse LRRK2. RRID:IMSR_JAX:013725
LRRK2 pS955 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine 955 of LRRK2.
HdAd5 3xFLAG-LRRK2 (wild-type)
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged WT LRRK2. HdAd5 FLAG-TK available as a control in Control section.
LRRK2 G2019S Mouse
Mouse Model
Transgenic mice overexpressing a mutant form (G2019S) of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene. RRID:IMSR_JAX:018785
LRRK2 A2016T Mouse
Mouse Model
Mice expressing the A2016T mutant (kinase inhibitor resistant) form of LRRK2. RRID:IMSR_JAX:021828
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"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic