To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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LRRK2 D1994A/R1441G Mouse
Mouse Model
Transgenic mice overexpressing both a mutant form D1994A and R1441G of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene.
Please note: Although founders were positively identified through genotyping and exhibited robust mRNA expression, these projects were halted due to a lack of any appreciable protein expression.
LRRK2 R1441G Mouse
Mouse Model
Transgenic mice overexpressing a mutant form (R1441G) of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene. RRID:IMSR_JAX:018786
LRRK2 KO Rat*
Rat Model
Homozygous rat knockout of LRRK2 created by 10 base pair deletion in Exon 30 in the Long Evans Hooded rat stain.
Alpha-Synuclein KO Mouse
Mouse Model
Homozygous knockout of alpha-synuclein created by deletion of SNCA exons 1-4 in the C57BL/6N mouse strain. RRID:IMSR_JAX:016123
LRRK2 D1994A Mouse
Mouse Model
Mice expressing the D1994A mutant (kinase-dead) form of LRRK2. RRID:IMSR_JAX:021830
Thy-1 Wild Type Human Alpha-Synuclein Mouse (Line 15)
Mouse Model
Transgenic mice expressing wild type human alpha-synuclein directed by the murine Thy-1 promoter. Two separate founder lines with different expression levels are available. RRID:IMSR_JAX:017682
Wild Type Human Alpha-Synuclein Mouse
Mouse Model
Mice express a wild-type human alpha-synuclein gene directed by its endogenous promoter/enhancer regions on the BAC transgene. RRID:IMSR_JAX:018442
LRRK2 KO Mouse
Mouse Model
Knockout of LRRK2 created by deletion of exons 39-40 of the LRRK2 gene in the C57BL/6N mouse strain. RRID:IMSR_JAX:016121
GBA D409V Knockin Mouse
Mouse Model
Knockin mice expressing the D409V mutant form of GBA on the C57BL/6N mouse background.
Generated as part of the Industry Tools Consortium. RRID:IMSR_JAX:019106
LRRK2 Plasmids
DNA Plasmids
DNA Plasmids encoding various LRRK2 cDNA inserts
Have questions or need additional information?
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"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic