To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
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Rab 29 Overexpression Mouse
Mouse Model
C57BL/6NTac mice constitutively over-expressing the wild type mouse Rab29 gene directed by the PGK promoter inserted via targeted mutagenesis in the ROSA26 locus.
Ubiquitinated-K266 VDAC1 Antibody
Antibody
Monoclonal antibody directed against ubiquitinated-K266 VDAC1. Please note: The antibody will not be made available as QC/QA of the antibody showed a lack of adequate sensitivity. Email tools@michaeljfox.org with questions or for more information.
LRRK2 pS935 Phosphospecific Antibody (UDD2)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine935 of LRRK2.
Rab 10 pT73 Phosphospecific Antibody (ICC/WB)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine73 of the Rab 10 protein. Recommended for immunostaining. Also suitable for immunoblotting although another antibody clone (ab230261) is more sensitive for that application.
AAV1/2-CAG-empty vector
Viral Vector
Viral Vector (AAV1/2 serotype) to serve as a control vector for the AAV1/2-CAG-A53T aSyn viral vector. The AAV-CAG-empty vector plasmid is also available in the Plasmid section.
AAV1/2-CAG-A53T Alpha-Synuclein
Viral Vector
Viral Vector (AAV1/2 serotype) encoding alpha-synuclein with the A53T mutation. AAV1/2 empty vector available as a control in Reporter section and the AAV-CAG-A53T alpha-synuclein plasmid is available in the Plasmid section.
Rab 8A ELISA*
Assay
ELISA kit designed for the quantitative measurement of Rab8A protein in human cell and tissue extract samples.
Rab 10 ELISA*
Assay
ELISA kit designed for the quantitative measurement of Rab10 protein in human, mouse and rat cell and tissue extract samples.
pT73 Rab 10 Protein
Protein
Phospho-T73 Rab10 synthetic phosphomimetic protein fragment (AA66-181) generated by native chemical ligation of recombinant peptides. This protein was designed and generated by X'PROCHEM.
PPMI iPSCs
Human iPS Cell
Induced pluripotent stem cell (iPSC) lines are available through the PPMI repository. The repository includes lines from control, idiopathic PD, genetic PD (LRRK2, GBA, SNCA), genetic unaffected carriers (LRRK2, LRRK2/GBA, GBA, SNCA), and prodromal patients. Gene-revertant controls are available for select lines. An inventory of available lines can be found here: https://zenodo.org/records/10783308
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic