To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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p62 pT138 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine 138 of the p62 protein. Suitable for immunoblotting applications.
Total Parkin Antibody*
Antibody
Monoclonal mouse antibody directed against human Parkin. Suitable for immunoblot and immunohistochemistry experiments.
Total Parkin Antibody*
Antibody
Monoclonal mouse antibody directed against human Parkin. Suitable for immunohistochemistry applications, and evidence suggests this antibody may be binding to a conformational epitope.
Humanized SNCA Mouse
Mouse Model
Mouse expressing the full human SNCA gene (including promoter, introns, and regulatory elements) without endogenous murine SNCA. Please note: MJFF was not successful in generating this line after multiple attempts. Alternative BAC human alpha-synuclein mouse lines are available at JAX.
Alpha-Synuclein Monomer Protein for PMCA/RT-QuIC Assays
Protein
Recombinant human alpha-synuclein monomeric protein designed to serve as substrate in PMCA/RT-QuIC assays.
Estimated Availability: Late 2025
Generated as part of the Industry Tools Consortium.
Rab 3 pT86 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine86 of Rab3. Suitable for immunoblot applications.
AAV2-CBA-Alpha-Synuclein
Viral Vector
Unavailable. Viral vector (AAV2 serotype) encoding wild-type alpha-synuclein. Produced by the UNC Vector Core.
Characterization data for this viral vector can be found here.
SNCA Multiplication iPSC Lines*
Human iPS Cell
Isogenic iPSC lines harboring a triplication , duplication, single copy, or KO of the SNCA gene derived from a patient with the triplication mutation. These lines were generated and kindly deposited by Birgitt Schuele at Stanford University into the MJFF Sponsored Tools Program.
LRRK2 KO MEF
Immortalized Cell
Mouse embryonic fibroblast line with knockout of LRRK2.
Expected availability: Mid 2025
LRRK2 G2019S KI MEF
Immortalized Cell
Mouse embryonic fibroblast line with knockin of the LRRK2 G2019S mutation.
Expected availability: Late 2025
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic