To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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ASAH1 Knockout A549 Cell Line
Immortalized Cell
A549 cell with homozygous knockout of ASAH1.
Estimated Availability: Early 2025
Alpha-Synuclein Ubiquitinated at K45/48/60 Antibody
Antibody
Rabbit monoclonal antibody directed against the K45/48/60-ubiquitinated alpha-synuclein.
Estimated Availability: Late 2025
Alpha-Synuclein pS129 Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine 129 of alpha-synuclein.
Alpha-Synuclein Preformed Fibril Protein*
Protein
Aggregated alpha-synuclein protein intended for use in synuclein seeding experiments.
Alpha-Synuclein N Terminal Antibody
Antibody
Rabbit monoclonal antibody directed against the N-terminal of human/mouse alpha-synuclein. Epitope has been mapped to amino acids 12-17 and 46-50 (due to sequence homology). Suitable for use in immunoblotting, immunocytochemistry, immunohistochemistry, and immunoassay.
Alpha-Synuclein Monomer Protein for PMCA/RT-QuIC Assays
Protein
Recombinant human alpha-synuclein monomeric protein designed to serve as substrate in PMCA/RT-QuIC assays.
Estimated Availability: Late 2025
Generated as part of the Industry Tools Consortium.
Alpha-Synuclein Monomer Protein
Protein
Full-Length human alpha-synuclein monomeric protein generated in vitro.
Note: This protein was used to generate alpha-synuclein filament which was then used as antigen for the MJF-14 alpha-synuclein filament-specific antibody which is also available at Abcam.
Alpha-Synuclein KO Rat
Rat Model
Sprague Dawley rat strain with CRISPR/Cas9 genome targeting strategy to KO endogenous alpha-synuclein.
Generated as part of the Industry Tools Consortium.
Alpha-Synuclein KO Mouse
Mouse Model
Homozygous knockout of alpha-synuclein created by deletion of SNCA exons 1-4 in the C57BL/6N mouse strain. RRID:IMSR_JAX:016123
Alpha-Synuclein Knockout Mouse*
Mouse Model
SCNA knockout mice carrying a 1164 bp fragment deletion in exon 2. Model was generated and deposited by Vladimir Buchman at Cardiff University School of Biosciences through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:028559
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic