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The Foundation has created a growing resource of research tools for the Parkinson's disease research and drug development community. Here you can search our catalogue of research tools by gene/protein of interest, type of tool and its availability.

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ALL RESEARCH TOOLS (75)

 

LRRK2 Knockout Rat

Type: Animal Model  |  Gene/Protein: LRRK2  |  Get it at SAGE Labs

Homozygous rat knockout of LRRK2 created by 10 base pair deletion in Exon 30.
50% discount to MJFF non-profit awardees

 

Parkin Knockout Rat

Type: Animal Model  |  Gene/Protein: Parkin  |  Get it at SAGE Labs

Homozygous rat knockout of LRRK2 created by 10 base pair deletion in Exon 30.
50% discount to MJFF non-profit awardees

 

DJ-1 Knockout Rat

Type: Animal Model  |  Gene/Protein: DJ-1  |  Get it at SAGE Labs

Homozygous rat knockout of DJ1 created by 8 base pair deletion plus 1 base pair substitution in Exon 5.
50% discount to MJFF non-profit awardees

 

Pink-1 Knockout Rat

Type: Animal Model  |  Gene/Protein: PINK1  |  Get it at SAGE Labs

Homozygour rat knockout of Pink1 created by 26 base pair deletion in Exon 4.
50% discount to MJFF non-profit awardees

 

LRRK2 Wild-type Mouse

Type: Animal Model  |  Gene/Protein: LRRK2  |  Get it at The Jackson Laboratory

Mice express a wild-type human LRRK2 gene directed by its endogenous promoter/enhancer regions on the BAC transgene. The human LRRK2 protein expression is approximately 5-fold over endogenous mouse LRRK2.
MJFF MTA agreement required

 

LRRK2 Knockout Mouse

Type: Animal Model  |  Gene/Protein: LRRK2  |  Get it at The Jackson Laboratory

Knockout mice lack exons 39-40 of the LRRK2 gene.
MJFF MTA agreement required

 

LRRK1 Knockout Mouse

Type: Animal Model  |  Gene/Protein: LRRK1  |  Get it at The Jackson Laboratory

Knockout mice lack exons 24-29 of the LRRK1 gene.
MJFF MTA agreement required

 

LRRK2 Antibody (MJFF2)

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Abcam

Rabbit monoclonal antibody directed against wild-type LRRK2. The antibody was mapped to the LRR domain of LRRK2 (AA 1035-1239).

 

LRRK2 Antibody (MJFF3)

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Abcam

Rabbit monoclonal antibody directed against wild-type LRRK2. The antibody was mapped to the LRR domain of LRRK2 (AA 1035-1239).

 

LRRK2 Antibody (MJFF4)

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Abcam

Rabbit monoclonal antibody directed against wild-type LRRK2. The antibody was mapped to the LRR domain of LRRK2 (AA 1035-1239).

 

LRRK2 Antibody (N241A/34)

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Neuromab

Mouse monoclonal antibody directed against wild-type LRRK2 using a fragment of LRRK2 (AA 970-2527).

 

LRRK2 Antibody (SIG-39840)

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Covance

Mouse monoclonal antibody generated in a mouse lacking endogenous LRRK2 protein using a peptide of LRRK2 (AA 2069-2087).

 

LRRK2 pS910 Phosphospecific Antibody (UDD1)

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Abcam

Rabbit monoclonal phosphospecific antibody directed against Serine910 of LRRK2.

 

LRRK2 pS935 Phosphospecific Antibody (UDD2)

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Abcam

Rabbit monoclonal phosphospecific antibody directed against Serine935 of LRRK2.

 

LRRK2 Antibody (UDD3)

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Abcam

Rabbit monoclonal antibody directed against the N-terminus (LRRK2(100-500)) of wild-type LRRK2. This antibody has been found to be superior in immunoprecipitation of LRRK2 from a variety of cell lysates and tissues.

 

LRRK2 pS910 Phosphospecific Antibody (1D8)

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Neuromab

Mouse monoclonal phosphospecific antibody directed against Serine910 of LRRK2.

 

AAV2-CBA-Alpha-Synuclein

Type: Viral Vector  |  Gene/Protein: Alpha-Synuclein  |  Get it at UNC Vector Core

Viral vector (AAV2 serotype) encoding wild-type alpha-synuclein.

 

AAV2-CBA-eGFP

Type: Viral Vector  |  Gene/Protein: eGFP  |  Get it at UNC Vector Core

Viral vector (AAV2 serotype) encoding eGFP to serve as a control vector.

 

AAV5-CBA-Alpha-Synuclein

Type: Viral Vector  |  Gene/Protein: Alpha-Synuclein  |  Get it at UNC Vector Core

Viral vector (AAV5 serotype) encoding wild-type alpha-synuclein.

 

AAV5-CBA-eGFP

Type: Viral Vector  |  Gene/Protein: eGFP  |  Get it at UNC Vector Core

Viral vector (AAV5 serotype) encoding eGFP to serve as a control vector.

 

LRRK2 Antibody (8G10)

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Neuromab

Mouse monoclonal antibody directed against wild-type LRRK2 using a fragment of LRRK2 (AA 100-500)

 

LRRK1/2 Double Knockout Mouse

Type: Animal Model  |  Gene/Protein: LRRK1  |  Get it at Jackson Laboratory

Double knockout mice lacking exons 39-40 of LRRK2 gene and exons 24-29 of LRRK1 gene

 

PINK1 Antibody

Type: Antibody  |  Gene/Protein: PINK1  |  Availability Expected 3rd Quarter 2014

Mouse monoclonal antibody directed against wild-type PINK1 using a fragment of PINK1 (AA 125-581)

 

TH- GFP Rat

Type: Animal Model  |  Gene/Protein: Tyrosine Hydroxylase  |  Availability Expected 3rd Quarter 2013

Rat expressing Green Fluorescent Protein (GFP) under rat Tyrosine Hydroxylase promotor.

 

Hd-Ad5 LRRK2 (G2019S)

Type: Viral Vector  |  Gene/Protein: LRRK2  |  Availability Expected 4th Quarter 2014

Helper-dependent Adenovirus 5 viral vectors expressing LRRK2 mutated at residue G2019S.

 

Lentiviral LRRK2 Viral Vectors -- LRRK2(G2019S/D1994A)

Type: Viral Vector  |  Gene/Protein: LRRK2  |  Get it at Leuven Viral Vector Core

Lentiviral vectors expressing LRRK2 mutated at residue G2019S.

 

LRRK2 pS973 Phosphospecific Antibody

Type: Antibody  |  Gene/Protein: LRRK2  |  Availability Expected 4th Quarter 2013

Rabbit monoclonal phosphospecific antibody directed against Serine 973 of LRRK2.

 

Alpha-Synuclein Filament-Specific Antibody

Type: Antibody  |  Gene/Protein: Alpha-Synuclein  |  Availability Expected 2nd Quarter 2014

Rabbit monoclonal antibody directed against the filamentous form of wild-type alpha-synuclein.

 

LRRK2 pT2483 Phosphospecific Antibody

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Abcam

Rabbit monoclonal phosphospecific antibody directed against Threonine 2483 of LRRK2.

 

Lentiviral LRRK2 Viral Vectors -- LRRK2(G2019S)

Type: Viral Vector  |  Gene/Protein: LRRK2  |  Get it at Leuven Viral Vector Core

Lentiviral vectors expressing wild-type LRRK2.

 

Parkin pS65 Phosphospecific Antibody

Type: Antibody  |  Gene/Protein: Parkin  |  Availability Expected 2nd Quarter 2014

Rabbit monoclonal phosphospecific antibody directed against Serine 65 of Parkin.

 

VPS35 D620N Knockin Mouse

Type: Animal Model  |  Gene/Protein: VPS35  |  Availability Expected 1st Quarter 2014

Mice expressing the D620N mutant form of VPS35

 

LRRK2 D1994A/G2019S Mouse

Type: Animal Model  |  Gene/Protein: LRRK2  |  Model will no longer be available

Transgenic mice overexpressing both a mutant form D1994A and G2019S of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene.

Please note: Although founders were positively identified through genotyping and exhibited robust mRNA expression, these projects were halted due to a lack of any appreciable protein expression.

 

Alpha-Synuclein pS129 Antibody

Type: Antibody  |  Gene/Protein: Alpha-Synuclein  |  Get it at Abcam

Rabbit monoclonal phosphospecific antibody directed against Serine 129 of alpha-synuclein.

 

Oxidized-DJ-1-Specific Antibody

Type: Antibody  |  Gene/Protein: DJ-1  |  Get it at Abcam

Rabbit monoclonal phosphospecific antibody directed against oxidized DJ-1 protein.

 

Hd-Ad5 LRRK2 (G2019S/D1994A)

Type: Viral Vector  |  Gene/Protein: LRRK2  |  Availability Expected 4th Quarter 2014

Helper-dependent Adenovirus 5 viral vectors expressing LRRK2 mutated at residues G2019S and D1994A.

 

LRRK2 pS955 Phosphospecific Antibody

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Abcam

Rabbit monoclonal phosphospecific antibody directed against Serine 955 of LRRK2.

 

PINK1 pT257 Phosphospecific Antibody

Type: Antibody  |  Gene/Protein: PINK1  |  Availability Expected 2nd Quarter 2014

Rabbit monoclonal phosphospecific antibody directed against Threonine 257 of PINK1.

 

LRRK2 ELISA

Type: Biochemical Assay  |  Gene/Protein: LRRK2  |  Availability Expected 2nd Quarter 2014

Quantitative assay for LRRK2 protein in biological samples

 

Cell line stably expressing wild-type LRRK2 (Type: Raw 264.7 macrophages)

Type: Cell Lines  |  Gene/Protein: LRRK2  |  Availability Expected 3rd Quarter 2014

Full-length human LRRK2 wild-type protein (1-2527 amino acids) was knocked in using zinc-finger nuclease (ZFN)-assisted adeno virus vector (AAV) technology to generate a stable cell line.

 

Hd-Ad5 LRRK2 (wild-type)

Type: Viral Vector  |  Gene/Protein: LRRK2  |  Availability Expected 4th Quarter 2014

Helper-dependent Adenovirus 5 viral vectors expressing wild-type LRRK2.

 

LRRK2 BAC G2019S Mouse

Type: Animal Model  |  Gene/Protein: LRRK2  |  Availability Expected 4th Quarter 2013

Transgenic mice overexpressing a mutant form (G2019S) of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene

 

LRRK2 A2016T Knockin Mouse

Type: Animal Model  |  Gene/Protein: LRRK2  |  Availability Expected 4th Quarter 2013

Mice expressing the A2016T mutant (LRRK2-IN1 resistant) form of LRRK2

 

LRRK2 D1994A Mouse

Type: Animal Model  |  Gene/Protein: LRRK2  |  Model will no longer be available

Transgenic mice overexpressing a mutant form (D1994A) of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene.

Please note: Although founders were positively identified through genotyping and exhibited robust mRNA expression, these projects were halted due to a lack of any appreciable protein expression.

 

LRRK2 D1994A/R1441G Mouse

Type: Animal Model  |  Gene/Protein: LRRK2  |  Model will no longer be avilable

Transgenic mice overexpressing both a mutant form D1994A and R1441G of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene.

Please note: Although founders were positively identified through genotyping and exhibited robust mRNA expression, these projects were halted due to a lack of any appreciable protein expression.

 

LRRK2 BAC R1441G Mouse

Type: Animal Model  |  Gene/Protein: LRRK2  |  Availability Expected 4th Quarter 2013

Transgenic mice overexpressing a mutant form (R1441G) of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene

 

Alpha-synuclein Knockout Mouse

Type: Animal Model  |  Gene/Protein: Alpha-Synuclein  |  Get it at The Jackson Laboratory

Knockout mice lack exons 1-4 of the Alpha-synuclein gene

 

LRRK2 D1994A Knockin Mouse

Type: Animal Model  |  Gene/Protein: LRRK2  |  Availability Expected 4th Quarter 2013

Mice expressing the D1994A mutant (Kinase-dead) form of LRRK2

 

Thy-1 Wild type Human Alpha-synuclein Mouse

Type: Animal Model  |  Gene/Protein: Alpha-Synuclein  |  Get it at Jackson Laboratory

Transgenic mice expressing wild type human Alpha-synuclein directed by the murine Thy-1 promoter.Two separate founder lines with different expression levels are available.

 

Wild type Human Alpha-synuclein Mouse

Type: Animal Model  |  Gene/Protein: Alpha-Synuclein  |  Availability Expected 3rd Quarter 2013

Mice express a wild-type human Alpha-synuclein gene directed by its endogenous promoter/enhancer regions on the BAC transgene

 

GBA D409V Knockin Mouse

Type: Animal Model  |  Gene/Protein: GBA  |  Availability Expected 2nd Quarter 2013

Mice expressing the D409V mutant form of GBA

 

LRRK2 Plasmids

Type: DNA Plasmids  |  Gene/Protein: LRRK2  |  Get it at Addgene

DNA Plasmids encoding various LRRK2 cDNA inserts

 

DJ-1 Plasmids

Type: DNA Plasmids  |  Gene/Protein: DJ-1  |  Get it at Addgene

DNA Plasmids encoding various DJ-1 cDNA inserts

 

LRRK2 T1348N Knockin Mouse

Type: Animal Model  |  Gene/Protein: LRRK2  |  Availability Expected 2nd Quarter 2014

Mice expressing the T1348N mutant (GTPase-dead) form of LRRK2

 

Alpha-synuclein Knockout Rat

Type: Animal Model  |  Gene/Protein: Alpha-Synuclein  |  The model will no longer be available

Please note: There was no germ line transmission obtained during the development of the rat.

 

EIF4G1 R1207H Knockin Mouse

Type: Animal Model  |  Gene/Protein: EIF4G1  |  Availability Expected 2nd Quarter 2014

Mice expressing the R1207H mutant form of EIF4G1

 

VPS35 D620N Knockin Mouse

Type: Animal Model  |  Gene/Protein: VPS35  |  Availability Expected 3rd Quarter 2013

Mice expressing the D620N mutant form of VPS35

 

DNAJ26 Plasmids

Type: DNA Plasmids  |  Gene/Protein: DNAJ26  |  Get it at Addgene

DNA Plasmids encoding various DNAJ26 cDNA inserts

 

LRRK2 pT1410 Phosphospecific Antibody

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Abcam

Rabbit monoclonal phosphospecific antibody directed against Threonine1410 of LRRK2.

 

Alpha-Synuclein ELISA Assay

Type: Biochemical Assay  |  Gene/Protein: Alpha-Synuclein  |  Get it at Covance

ELISA kit developed in collaboration with Covance for measuring human alpha-synuclein protein in biological samples.

The assay has been demonstrated to conform to AAPS performance criteria using CSF as a matrix.

 

LRRK2 pT1491 Phosphospecific Antibody

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Abcam

Rabbit monoclonal phosphospecific antibody directed against Threonine1491 of LRRK2.

 

Alpha-Synuclein Antibody

Type: Antibody  |  Gene/Protein: Alpha-Synuclein  |  Get it at Abcam

Rabbit monoclonal antibody directed against wild-type human alpha-synuclein. The antibody was mapped to the LRR domain of LRRK2 (AA 1035-1239).

 

Microtubule-Associated Protein Tau Plasmids

Type: DNA Plasmids  |  Gene/Protein: MAPT  |  Get it at Addgene

DNA Plasmids encoding various MAPT cDNA inserts

 

VPS35 Plasmids

Type: DNA Plasmids  |  Gene/Protein: VPS35  |  Get it at Addgene

DNA Plasmids encoding various VPS35 cDNA inserts

 

PINK1 Plasmids

Type: DNA Plasmids  |  Gene/Protein: PINK1  |  Get it at Addgene

DNA Plasmids encoding various PINK1 cDNA inserts

 

Parkin Plasmids

Type: DNA Plasmids  |  Gene/Protein: Parkin  |  Get it at Addgene

DNA Plasmids encoding various Parkin cDNA inserts

 

LRRK2 pT1503 Phosphospecific Antibody

Type: Antibody  |  Gene/Protein: LRRK2  |  Get it at Abcam

Rabbit monoclonal phosphospecific antibody directed against Threonine1503 of LRRK2.

 

LRRK2 Full-Length Protein (Human)

Type: Protein  |  Gene/Protein: LRRK2  |  Get it at Life Technologies

Full-Length human LRRK2 protein generated in vitro and assessed for kinase activity.

 

Lentiviral LRRK2 Viral Vectors -- eGFP-LRRK2 (wild-type)

Type: Viral Vector  |  Gene/Protein: LRRK2  |  Get it at Leuven Viral Vector Core

Lentiviral vector encoding wild-type LRRK2

 

Lentiviral Vectors -- eGFP

Type: Viral Vector  |  Gene/Protein: eGFP  |  Get it at Leuven Viral Vector Core

Lentiviral vector encoding eGFP

 

Hd-Ad5 eGFP

Type: Viral Vector  |  Gene/Protein: LRRK2  |  Availability Expected 4th Quarter 2014

Helper-dependent Adenovirus 5 viral vectors expressing eGFP.

 

LRRK2 pS1292 Phosphospecific Antibody

Type: Antibody  |  Gene/Protein: LRRK2  |  Availability Expected 2nd Quarter 2014

Rabbit monoclonal phosphospecific antibody directed against Serine 1292 of LRRK2.

 

Cell line stably expressing mutant LRRK2 T1348N (KI) (Type: Raw 264.7 macrophages)

Type: Cell Lines  |  Gene/Protein: LRRK2  |  Availability Expected 3rd Quarter 2014

Full-Length human LRRK2 protein expressing a T1348N mutation in exon 41 was knocked in using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line

 

Cell line stably expressing mutant LRRK2 G2019S (KI) (Type: Raw 264.7 macrophages)

Type: Cell Lines  |  Gene/Protein: LRRK2  |  Availability Expected 3rd Quarter 2014

Full-Length human LRRK2 protein expressing a G2019S mutation in exon 41 was knocked in using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line

 

Cell line stably expressing mutant LRRK2 P2017A/G2019S (KI) (Type: Raw 264.7 macrophages)

Type: Cell Lines  |  Gene/Protein: LRRK2  |  Availability Expected 3rd Quarter 2014

Full-Length human LRRK2 protein expressing two mutations P2017A and G2019S - in exon 41 was knocked in using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line

 

 

 

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