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Assessing Parkinson’s at Home: Contactless Monitoring of Sleep, Motor Symptom Progression and Medication Response
… continuous and convenient measurement of Parkinson’s health metrics can facilitate shorter clinical trials with …
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Changing Rhythms in Parkinson’s Disease: Development of Motor and Non-motor Markers of Progression Based on Continuous Daily Monitoring
… continuous and objective measurements of the day-to-day health and activity of people with PD, we expect that …
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Development of Parkin Activators for the Treatment of Parkinson’s Disease
… Study Rationale: Impaired function of cell structures called mitochondria plays a key role in … mitochondrial health and protect dopamine neurons in people with PD. Hypothesis: The death of dopamine-producing … in cellular and preclinical PD models. Impact on Diagnosis/Treatment of Parkinson’s disease: Our approach has the …
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Developing Small Molecules to Enhance Autophagy and Clear Alpha-synuclein Aggregates as a Treatment for Parkinson’s Disease
… subsequently determine whether the treatment provided any health benefits. This assessment will be done via movement …
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Development of Biomarkers Based on Brainstem Nuclei for Prodromal Parkinson's Disease
… nuclei to MRIs of prodromal PD, recently diagnosed PD and healthy subjects from the … whether these values differ in people with PD compared to healthy subjects and whether they diminish with disease … identify the location of brainstem nuclei in MRI of health and disease, including PD. Next Steps for …
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Episode 5: The Role of Inflammation and Immune Responses in Neurodegeneration with Malú Gámez Tansey
December 19, 2023
… the links between inflammation, our immune responses, brain health, and neurodegeneration. In particular, several genes …