Intestinal and Nasal Microbiota of Patients with Idiopathic Parkinson's disease
Rapid Response Innovation Awards, 2012
The research from this grant has continued with the supplementary grant:
- The Microbiome in Parkinson's Disease: Role as a Potential Biomarker and Relation to Disease Progression
The cause of Parkinsonís disease is unknown and a reliable biomarker to identify Parkinsonís disease patients as early as possible is urgently needed. Nerve cells near the nose and in the gut become first affected in Parkinsonís disease and patients frequently suffer from loss of smell and constipation. The nose and gut harbor very high amounts of bacteria that influence our body functions in many ways, even in the brain. We are investigating a possible role of bacteria of the nose and gut in the pathogenesis of Parkinsonís disease. This may lead to a better understanding of what Parkinsonís disease causes and may open new possibilities for diagnosis and treatment.
We will recruit 100 Parkinsonís disease patients and 100 control subjects. We will characterize all subjects carefully with respect to clinical symptoms. We will collect bacterial samples from the nose and stool of these subjects. Using modern genomic techniques we will read out the genetic code of all bacteria contained in these samples and will be able to identify which species of bacteria are present in the samples. Using complex cluster computing we will compare the pattern of bacterial species between Parkinsonís disease patients and controls and look for specific abnormalities in Parkinsonís disease patients.
Relevance to Diagnosis/Treatment of Parkinsonís Disease:
If we can detect specific differences of bacterial communities between Parkinsonís disease patients and controls this may point to a role of bacteria as a cause of Parkinsonís disease. Since there are many ways to influence bacterial communities pharmacologically (antibiotics, probiotics) it will be possible to investigate whether these therapies could alleviate or even reverse Parkinsonís disease symptoms. Furthermore, we would be able to use these differences as a biomarker which would enable us to develop a quick screening test for bacterial samples that may reveal whether a person has Parkinsonís disease or not.
By doing this study we will learn whether bacteria play a role in the development of Parkinsonís disease and whether we can use them as a biomarker or therapeutic target. Hopefully, we will be able in the future to better understand what causes Parkinsonís disease, how we can diagnose it as early as possible and how to cure patients from Parkinsonís disease.
Location: Espoo, Finland
Neurologist at Helsinki University Central Hospital
Location: Helsinki, Finland
Location: Hyvinkšš, Finland