Quinpramine for Parkinsonís Disease
Synuclein Therapeutic Acceleration Program, 2013
Objective/Rationale: † † † † † ††
A part of Parkinsonís disease progression involves abnormal aggregation of normal brain proteins into knots of insoluble irritant material. The protein involved in many cases is alpha-synuclein. Preventing these knots starting, or stopping them increasing in size, is one possible means of treating the disease. †We have a drug candidate that prevents the proteins from grouping together on the outside of cells. The candidate is a combination of two known compounds. †It is in an early stage of pharmacological testing.
Project Description: † † † † † ††
The project will study our candidate drug, quinpramine, in pre-clinical models for Parkinsonís disease. First the oral dosage forms of quinpramine will be studied in pre-clinical models to determine the doses and the dosing schedule for further experiments. Next, the drug will be evaluated in a Parkinsonís disease model overexpressing alpha-synuclein. Behavioral tests will assess the effect on disease symptoms while microscopy techniques will monitor effects on alpha-synuclein, neurodegeneration and inflammation. In addition, in preparation for the further development of quinpramine, we will make early safety assessments conducted to exclude unwanted adverse effects.
Relevance to Diagnosis/Treatment of Parkinsonís Disease: † † † † † † † † † ††
Quinpramine has the potential to be developed for the treatment of Parkinsonís disease by specifically interacting with alpha-synuclein. By doing so, the progression of the disease could be slowed down or stopped before it becomes severe.
Anticipated Outcome: † † † † †
The project should provide pre-clinical proof of concept for this molecule and prepare for the non-clinical development i.e. the assessment in regulatory-required toxicology studies as a pre-requisite for clinical testing.†
Managing Director at Synovo GmbH
Location: TŁbingen, Germany
Location: Monheim, Germany