The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant Supplement, 2015Hit-to-Lead Optimization of Parkin Activators through Structure-Function Analyses
Objective/Rationale:
This project aims to develop potent small molecule activators of Parkin, which is mutated in some forms of familial Parkinson’s disease and might also be inactivated... -
Research Grant, 2015Amelioration of Mitochondrial Oxidant Stress by Isradipine and Rasagiline
Study Rationale:
The cardinal motor symptoms of Parkinson’s disease (PD) are caused by the degeneration of dopaminergic neurons. One potential cause of this degeneration is calcium... -
Biomarker Development, 2015Biomarker and DNA Samples Collection Add-on Study to the Phase III Trial of Isradipine
Study Rationale:
Isradipine, an FDA-approved agent for treatment of high blood pressure, was shown to be have neuroprotective benefit in models of Parkinson’s disease (PD). A recently completed Phase... -
Access to Data and Biospecimens, 2015Validation of a Blood-based Gene Expression Assay for Early Diagnosis and Monitoring Disease
Study Rationale:
The need for biomarkers in Parkinson’s disease (PD) is crucial for the early diagnosis of PD; monitoring PD severity/progression; and developing treatments that can... -
Research Grant, 2015Pre-clinical Development of the Oligomer Modulator anle138b and Establishment of a Novel Seeding-based Biomarker
Promising Outcomes of Original Grant:
In our previous work, we assessed the therapeutic potential of the oligomer modulator anle138b in pre-clinical models of Parkinson’s disease (PD). Anle138b... -
Target Validation, 2015Enhancing Mitochondria Quality Control in Parkinson’s via Activation of the Caseinolytic Peptidase
Study Rationale:
Reinforcement of mechanisms that maintain the health of the cell’s energy generator, its mitochondria, may combat age-related diseases including Parkinson’s disease...
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Our funding programs support basic, translational and clinical research from academia and industry.