The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Cognitive Deficits and Mood Disorders in Parkinson's Disease, 2008Cognitive Decline in Parkinson's Disease
Objective/Rationale:
There are many studies on cognitive and behavioral alterations in Parkinson’s disease, but each of these investigations brought only a small piece of a large puzzle. Consequently... -
Program-non-specific Funding, 2008Validation of TorsinA as a Target for PD Therapy in Mammalian Models
Objective/Rationale:
Mutations in the protein torsinA cause a hereditary form of dystonia. While the normal function of torsinA is not entirely clear, it is thought to be a “chaperone,” a molecule... -
Rapid Response Innovation Awards, 2008Exploring a Novel Pathogenetic Mechanism in Parkinson's Disease
Objective/Rationale:
We recently reported that neuropathological changes gradually propagate from Parkinson disease patients’ brains to grafted neurons. Over one decade after graft surgery, we found... -
Development of Progressive Pre-clinical Models of PD, 2006Inflammatory Stimuli as 'Second-Hit' Triggers for Development of Progressive Nigral Degeneration
Parkin and DJ-1 knockout mice model the recessively inherited loss-of-function mutations in these genes that cause human parkinsonism. Despite significant nigrostriatal dysfunction in both knockout...
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Development of Progressive Pre-clinical Models of PD, 2006The PD Pre-Clinical Model: A Progressive Model of Parkinson's Disease with Key Pathology and Behavior Caused by Targeting Mitochondrial Function in Dopamine Neurons
Recent research suggests that there can be genetic causes of Parkinson's disease. In several forms of the disease, these genetic disturbances appear to compromise function of the cells' energy...
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Development of Progressive Pre-clinical Models of PD, 2006Rat Transgenic Models for Autosomal Dominant PD via BAC Technology
Animal models are crucial in the mechanistic study of Parkinson's disease and therapeutic development. However, a severe and unfortunate roadblock is that to date no genetic mammalian models have...
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