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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Parkinson’s Disease Therapeutics Pipeline Program, 2024
    Therapeutic Development of Novel STING Inhibitors to Treat Parkinson's Disease Neuroinflammation

    Study Rationale: Brain inflammation plays an important role in the pathology and progression of Parkinson’s disease (PD). One of the key proteins involved in this inflammatory process is STING...

  • Neuronal Synuclein Disease Endotypes 2024, 2025
    BIOLOGY IS THE DISEASE: Identifying Biological Endophenotypes Based on Alpha-synuclein and AD Pathology Profiles and Evaluate NSD-ISS Stage 3-6

    Study Rationale: In the era where we aim to define diseases by biology and modifying treatment options become available for neurodegenerative diseases, the clinicopathological heterogeneity in alpha...

  • Therapeutic Pipeline Program, 2016
    Effect of HDAC Inhibition in Models of Parkinson's Disease

    Study Rationale:
    Numerous publications have linked the family of epigenetic enzymes known as HDACs (histone deactylases) to the underlying pathology of Parkinson's. This study will test the efficacy of...

  • Parkinson’s Disease Therapeutics Pipeline Program, 2025
    ACT-02 as a Disease-modifying Therapy for Parkinson’s

    Study Rationale: Parkinson’s disease (PD) is a complex neurodegenerative disorder marked by the loss of dopaminergic neurons, however the underlying exact reasons are still not fully understood...

  • Rapid Response Innovation Awards, 2007
    Everyday Action Impairment in People with Parkinson's Disease Dementia/Dementia with Lewy Bodies

    Objective/Rationale:
    Parkinson’s disease (PD) and Parkinson’s Disease Dementia/Dementia with Lewy Bodies (PDD/DLB) have been associated with cognitive deficits and everyday action impairment (EAI; e.g...

  • Cognitive Deficits and Mood Disorders in Parkinson's Disease, 2008
    A Rodent Model of Pathological Gambling Associated with Medicated Parkinsonian Patients

    Objective/Rationale:
    The increase in impulsive and risky behaviors, like gambling, hyper-sexuality, and compulsive shopping are emotionally and financially devastating, and impose a significant burden...

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