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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2009
    Rational Vectors For PD

    Objective/Rationale:
    The project is hot on the trail of key suspect players in Parkinson’s disease. The output of an innovative screening process put forth a handful of candidate enzymes in a lower...

  • Rapid Response Innovation Awards, 2009
    From Anti-aggregation Assay to Treatment for Parkinson's Disease: Developing a Secondary Screen to Bridge High throughput Screen and Cellular Assay

    Objective/Rationale:
    We want to develop a series of secondary assays that will allow us to shortlist likely drug candidates for therapy against Parkinson’s disease. These assays will bridge the gap...

  • Rapid Response Innovation Awards, 2009
    Investigating the Potential effect of Peroxisome Proliferation in Diminishing Alpha-synuclein Pathogenesis

    Objective/Rationale:
    Alpha-synuclein is a protein critically involved in the pathogenesis of Parkinson’s disease. Growing evidence link alpha-synuclein  pathogenesis in PD and brain lipid metabolism...

  • Rapid Response Innovation Awards, 2009
    Crystal Structure of Alpha-Synuclein; Toward Rational Drug Design

    Objective/Rationale: The alpha-synuclein is implicated in the pathogenesis of Parkinson’s disease. An aggregated form of synuclein containing many molecules has been proposed to interact destructively...

  • Rapid Response Innovation Awards, 2009
    Probing the Neuroprotective Effects of Haploinsufficiency of RanBP2 in Neurotoxicant-induced Experimental Pre-clinical Models of Parkinson's Disease

    Objective/Rationale:
    A partial deficit in the level of Ran-binding protein-2 (RanBP2) confers neuroprotection to neurons upon aging and deleterious stimuli promoting oxidative stress, a stress...

  • Rapid Response Innovation Awards, 2009
    Identification of Substrates and Development of a Cell Based Assay for LRRK2

    Objective/Rationale:
    Inherited mutations in a gene called LRRK2 have recently been discovered to cause Parkinson’s disease. The LRRK2 gene encodes an enzyme called a kinase, which is more active when...

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