The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2019The Synaptic Vesicle Cycle in Parkinson’s Disease
Study Rationale:
Many of the proteins implicated in Parkinson’s disease appear to have a role at the nerve terminal, presumably in neurotransmitter release. However, the function of most has remained... -
Target Advancement Program, 2019Targeting Necroptosis to Stop Axonal Degeneration in Parkinson's Disease
Study Rationale:
Parkinson’s disease (PD) is caused by degeneration of dopamine neurons. Neurons are constituted by a cell body and projections called axons by which neurons communicate... -
Target Advancement Program, 2019GBA Stabilization through Nanobodies
Study Rationale:
Mutations in the GBA gene are a known genetic risk factor for Parkinson’s disease and cause reduced stability and activity of the GBA protein. This can contribute to the impairment of... -
LRRK2 Biology Consortium, 2019Biochemical and Structural Characterization of LRRK2-specific Nanobodies
Study Rationale:
Malfunctioning of the protein leucine-rich repeat kinase 2 (LRRK2) is a common genetic cause of Parkinson’s disease (PD). LRRK2 is a very large and complex protein, and insight into t... -
Research Grant, 2019Functional Evaluation of Alpha-synuclein Dosage Effects in CRISPR‐edited SNCA Model
Promising Outcomes of Original Grant:
The goal of our original grant was to develop a patient-derived stem cell model from skin cells with different expression levels of protein alpha-synuclein, which... -
GBA Biology and Therapies, 2019Expression of GCase throughout Brain Vasculature for Degradation of Alpha-synuclein Aggregates
Study Rationale:
Alpha-synuclein toxicity is caused by progressive accumulation of this protein in cells. Alpha-synuclein protein aggregation is helped along by impaired lysosomes...
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Our funding programs support basic, translational and clinical research from academia and industry.