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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Postural Instability and Gait Disturbances, 2009
    Relationship between REM Behavior Disorder and Freezing of Gait in Parkinson's Disease

    Objective/Rationale:
    Many people with REM sleep behavior disorder (RBD), a disease associated with disturbance of sleep, eventually develop Parkinson’s disease. Dysfunction and degeneration of...

  • Postural Instability and Gait Disturbances, 2009
    Determining the Neural Correlates of Freezing of Gait in Parkinson's Disease Using Functional Magnetic Resonance Imaging

    Objective/Rationale:
    Freezing of Gait (FOG) in Parkinson’s disease occurs when a person’s feet become suddenly ‘frozen’ while walking or turning. FOG is a leading cause of falls, and responds poorly to...

  • Postural Instability and Gait Disturbances, 2009
    The Role of White Matter Pathology in the Development of the Postural Instability and Gait Disturbance (PIGD) Type of Parkinson's Disease (PD)-1

    Objective/Rationale:
    It is not clear why a subset of patients with Parkinson's disease develop postural instability and gait disturbances (PIGD), while others do not. White matter (WM) changes that...

  • MJFF Research Grant, 2009
    Pilot Assessment of the Effect of Optimism and Expectation on Dyskinesia Rating Scales in Parkinson's Disease Subjects Randomized to Placebo or Amantadine

    Objective/Rationale:
    The effects of placebo response in clinical and surgical interventions in PD have become increasingly recognized. Many factors have been associated with placebo response including...

  • Rapid Response Innovation Awards, 2008
    Expression, Purification and Crystallization of the LRRK2 Kinase

    Objective/Rationale:
    Mutations in the gene encoding Leucine Rich Repeat Kinase 2 (LRRK2) are found in a substantial number of patients with familial or sporadic forms of Parkinson’s disease, and it has...

  • Rapid Response Innovation Awards, 2008
    Evaluation of LRRK2 Inhibitors in the LRRK2 Drosophila PD Model

    Objective/Rationale: 
    Biochemical evidence suggests that aberrant GTPase and kinase activities are linked to disease causing mutations in LRRK2, and may be at the basis of neuronal toxicity and...

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