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Darren J. Moore, PhD

Professor, Center for Neurodegenerative Science at Van Andel Research Institute
Location: Grand Rapids, MI United States

Dr. Moore received his PhD in molecular neuroscience from the University of Cambridge in 2001 in the laboratory of Piers Emson and conducted postdoctoral research with Ted Dawson in the Institute for Cell Engineering and Udall Parkinson’s Disease Center of Excellence at the Johns Hopkins University School of Medicine. He joined the Department of Neurology faculty at Johns Hopkins in 2006 as Assistant Professor, before moving to the Brain Mind Institute of the Swiss Federal Institute of Technology (EPFL) in 2008. In 2014, Dr. Moore was appointed as Associate Professor in the newly created Center for Neurodegenerative Science at the Van Andel Institute in Michigan, becoming Full Professor in 2017, and appointed as Department Chair in 2020. His research focuses on understanding the cell biology and pathophysiological mechanisms underlying familial genes for PD, including LRRK2, VPS35, α-synuclein and ATP13A2, and their contributions to the endolysosomal pathway.


Associated Grants

  • Evaluation of ATP13A2 as a Molecular Target for Ameliorating Alpha-Synuclein-Induced Neurodegeneration in Pre-clinical Models of PD

    2011


  • Validation of Enzymatic Activity and Neuropathology in G2019S LRRK2-induced Dopaminergic Neurodegeneration in a Pre-clinical Model of Parkinson's Disease

    2010


  • Identification of LRRK2 Substrates in Pre-clinical Models of Parkinson's Disease

    2009


  • Generation of Transgenic Mice with Selective and Progressive Loss of Nigrostriatal Dopaminergic Neurons

    2006


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