… years also induces severe secondary effects known as dyskinesia. Such secondary effects seriously limit the … to understand the mechanisms involved in levodopa-induced dyskinesia. The objective of the project is to demonstrate … its protein product in the development of levodopa-induced dyskinesia. Project Description: The role of the Gad1 gene …

… the only available medication to treat levodopa-induced dyskinesia: involuntary, jerky movements caused by long-term … levodopa. However, the dose of amantadine that helps treat dyskinesia is associated with side effects such as cognitive … is sought. A compound called fenobam showed an effect on dyskinesia in pre-clinical models. This study will test the …

… Objective/Rationale: Levodopa-induced dyskinesias (LID) affect the majority of patients with … LID. The impact of the drug on the severity and duration of dyskinesias, as well as the anti-parkinsonian effects of … and safety of a novel agent in reducing levodopa-induced dyskinesia (LID) in a pre-clinical model of Parkinson’s …

… models have an altered onset of levodopa induced dyskinesia, a major side effect that occurs after chronic … been linked to the development of levodopa induced dyskinesia are changed.  We will also investigate whether a … CK2 has a similar effect on the onset of levodopa induced dyskinesia than the knockout pre-clinical model. We will …

… however long-term use leads to disabling L-DOPA-induced dyskinesia (LID) in the vast majority of patients. NMDA … or avoiding treatment-induced complications such as dyskinesia, which affects the long term efficacy of the … we assessed the ability of anesthetic gas xenon to prevent dyskinesia -- drug-induced involuntary movements -- in a …

… levodopa treatment, can cause abnormal movements called dyskinesia. Previous studies in PD and in laboratory models showed that dextromethorphan can reduce dyskinesia at doses that are well tolerated. This study will … and quinidine) in the treatment of levodopa-induced dyskinesia in PD patients. Project Description: …