… of this project is to study mechanisms responsible for the dyskinesia side effect of levodopa seen in patients with … for a long period of time. Accordingly, FOSB could mediate dyskinesias long after the last levodopa treatment is given. …

… Neoangiogenesis and Blood-Brain Barrier in L-DOPA-induced Dyskinesia Levodopa is still the most effective treatment … a great potential to induce abnormal involuntary movements (dyskinesia). Working on a pre-clinical model of PD, we have …

… levels of levodopa play a key role in the production of dyskinesia (abnormal involuntary movements) and motor … in BBB permeability) contribute to the development of dyskinesias in PD. Dr. Cenci is now collaborating with Dr. …

… Neoangiogenesis and Blood-Brain Barrier in L-DOPA-induced Dyskinesia Promising Outcomes of Original Grant : Working on … correlates with the severity of the motor complications (dyskinesia) induced by levodopa. Treatments that inhibit …

… part of the brain called the striatum in levodopa-induced dyskinesia. This small population of striatal neurons has … activities of striatal cholinergic interneurons can alter dyskinesia. Study Design: We will test methods to modulate …

… D4 Antagonists for the Treatment of Levodopa-induced Dyskinesia Promising Outcomes of Original Grant: In our … the lead molecule in a pre-clinical model of L-DOPA-induced dyskinesias (LIDs), disabling involuntary movements caused …