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Clinical Trials Studying Dyskinesia
January 13, 2012
… Many people with Parkinson’s disease eventually develop dyskinesias [dis-kuh-NEE-zhuhs] — abnormal and unwanted … subtle to extremely debilitating, and for some people, dyskinesias interfere with everyday activities such as … are studying the effectiveness of new therapies to treat dyskinesias. Here are just a few for your consideration: …
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Simvastatin for the Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease
… Objective/Rationale: Levodopa-induced dyskinesias are caused by an increased response of dopamine … the MAP kinase — versus placebo on levodopa-induced dyskinesias in Parkinson’s disease (PD) patients. Project … in adjunct therapy to levodopa, in the treatment of dyskinesias in Parkinson’s disease without aggravating the …
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Role of mGluR4 in the Modulation of Levodopa-induced Motor Performance and Dyskinesia
… Objective/Rationale : Dyskinesias are uncontrollable involuntary body movements … combination with L-DOPA on the induction of L-DOPA related dyskinesias in a well known pre-clinical model of PD. … approach for PD and the reduction of L-DOPA induced dyskinesias. In addition, these studies will provide …
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Podcast: What Causes Dyskinesia?
January 18, 2016
… disease and use of Parkinson's medications are called dyskinesia. In our latest podcast Christopher Bishop, PhD, of Binghamton University, discusses what may cause dyskinesia with medication use. "There are two sides to … insult and injury, but there’s a tipping point, and with dyskinesia in particular we believe that that positive …
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Prevention of Levodopa-induced Dyskinesia by Transcranial Static Magnetic Field Stimulation
… Parkinson’s treatment is the management of levodopa-induced dyskinesias. A promising approach is offered by non-invasive … of tSMS as a novel approach to manage levodopa-induced dyskinesia in Parkinson’s disease. Hypothesis: Our central … in Parkinson’s disease will decrease levodopa-induced dyskinesia. Study Design: This project is composed of three …
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Multi-single Unit Electrophysiological Characterization of Dyskinesia Induced by Dopamimetic Drugs
… phenomena, it is known that these complications, named 'dyskinesia', are accompanied by a dramatic reduction in the … disease. More recently, it has been proposed that the dyskinesia might also be accompanied by an increased … correlates of levodopa-induced and dopamine agonist-induced dyskinesia using multi-single-unit recording with special …