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Clinical Trials Studying Dyskinesia
January 13, 2012
… Many people with Parkinson’s disease eventually develop dyskinesias [dis-kuh-NEE-zhuhs] — abnormal and unwanted … subtle to extremely debilitating, and for some people, dyskinesias interfere with everyday activities such as … are studying the effectiveness of new therapies to treat dyskinesias. Here are just a few for your consideration: …
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Podcast: What Causes Dyskinesia?
January 18, 2016
… to correct slowness and rigidity, but sometimes they can cause too much motion. The involuntary, jerky movements … long-term disease and use of Parkinson's medications are called dyskinesia. In our latest podcast Christopher Bishop, … exogenous compounds like dopamine agonists and especially levodopa, then the response shifts from improving poor …
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Simvastatin for the Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease
… Objective/Rationale: Levodopa-induced dyskinesias are caused by an increased response of dopamine … the MAP kinase — versus placebo on levodopa-induced dyskinesias in Parkinson’s disease (PD) patients. Project … in adjunct therapy to levodopa, in the treatment of dyskinesias in Parkinson’s disease without aggravating the …
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Role of mGluR4 in the Modulation of Levodopa-induced Motor Performance and Dyskinesia
… Objective/Rationale : Dyskinesias are uncontrollable involuntary body movements … combination with L-DOPA on the induction of L-DOPA related dyskinesias in a well known pre-clinical model of PD. … approach for PD and the reduction of L-DOPA induced dyskinesias. In addition, these studies will provide …
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Prevention of Levodopa-induced Dyskinesia by Transcranial Static Magnetic Field Stimulation
… Parkinson’s treatment is the management of levodopa-induced dyskinesias. A promising approach is offered by non-invasive … of tSMS as a novel approach to manage levodopa-induced dyskinesia in Parkinson’s disease. Hypothesis: Our central … in Parkinson’s disease will decrease levodopa-induced dyskinesia. Study Design: This project is composed of three …
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Multi-single Unit Electrophysiological Characterization of Dyskinesia Induced by Dopamimetic Drugs
… phenomena, it is known that these complications, named 'dyskinesia', are accompanied by a dramatic reduction in the … disease. More recently, it has been proposed that the dyskinesia might also be accompanied by an increased … correlates of levodopa-induced and dopamine agonist-induced dyskinesia using multi-single-unit recording with special …