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Adenosine A2A Receptors in a Pre-clinical Model of PD Dyskinesias
… of involuntary jerking and twisting movements known as dyskinesias, which in some patients are as disabling as the …
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Peroxisome-Proliferator Activated Receptor gamma as a Target for Anti-Dyskinesia Pharmacotherapy
… new pharmacological approaches to treat levodopa-induced dyskinesia (LID) in a pre-clinical model of Parkinson’s … ameliorates levodopa-induced oral, axial and limb dyskinesias in 6-OHDA-treated pre-clinical models of …
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Development of Functional Imaging for CB-1 and 5-HT1a in PD Participants with Dyskinesia
… receptors may play an important role in levodopa-induced dyskinesia. The development of imaging tests to evaluate the … to develop medications that more effectively treat dyskinesias. Project Description: Six PD subjects with …
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Levodopa-induced dyskinesias result from dysregulation of intraneuronal trafficking of dopamine receptors
… Involuntary movements, or dyskinesias, represent a debilitating complication of … by the vast majority of the patients. We hypothesize that dyskinesia may be caused, at least in part, by changes in …
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Prevention of Levodopa-induced Dyskinesia by Transcranial Static Magnetic Field Stimulation
… Parkinson’s treatment is the management of levodopa-induced dyskinesias. A promising approach is offered by non-invasive …
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Functional Inhibition of RasGRF1 in the MPTP-lesioned NHP Model for Treating Levodopa-induced Dyskinesia
… Objective/Rationale: Levodopa-induced dyskinesias are caused by an increased and aberrant response …