… of involuntary jerking and twisting movements known as dyskinesias, which in some patients are as disabling as the … potential to treat the symptoms of PD without exacerbating dyskinesias. Although initial clinical trials have indeed … blockade in advanced PD patients who had already developed dyskinesias, the effect of of A2A blockers on the …

… Involuntary movements, or dyskinesias, represent a debilitating complication of … by the vast majority of the patients. We hypothesize that dyskinesia may be caused, at least in part, by changes in … of dopamine receptors and the occurrence and/or severity of dyskinesia. Such an investigation would help to define the …

… D4 Antagonists for the Treatment of Levodopa-induced Dyskinesia Promising Outcomes of Original Grant: In our … the lead molecule in a pre-clinical model of L-DOPA-induced dyskinesias (LIDs), disabling involuntary movements caused … progress into pre-clinical testing. … Neuropharmacology … Dyskinesia … Nebraska … Therapeutic Development … Research …

… recently shown that, in the context of levodopa-induced dyskinesias, the debilitating motoric manifestation that … of dyskinetic non-human primates, hoping to abolish the dyskinesia severity. If successful, our strategy could be … demonstrated that abnormal involuntary movements and dyskinesia are lessened by overexpression of GRK6 in …

… as an appealing target for managing levodopa-induced dyskinesia and therefore received attention from industry, … current concept of MOR antagonization for levodopa-induced dyskinesia management. Project Description: Building upon … future development of drugs interacting with MOR for dyskinesia or will kill the target. This is a required step …

… of this project is to study mechanisms responsible for the dyskinesia side effect of levodopa seen in patients with … for a long period of time. Accordingly, FOSB could mediate dyskinesias long after the last levodopa treatment is given. … the hypothesis that FOSB is one cause of levodopa-induced dyskinesia and that blockade of FOSB reduces the dyskinesias …