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Targeting Dramatically Activated Astrocytic Networks for Managing LID: a Target Validation Program
… their role in Parkinson’s disease and levodopa- induced dyskinesia pathological changes has remained almost … in new pathophysiological and therapeutic directions. … Dyskinesia … Clinical Trial … Alabama … United States … Dyskinesia … Erwan Bezard, PhD … Jérôme Baufreton, PhD …
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Caffeine and the Risks of Disease Progression and Dyskinesias in PD
… to repeated L-dopa treatment in an animal model of the dyskinesias, which are a major complication of L-dopa … (1) disease progression in PD, and (2) the development of dyskinesias and other dopaminergic motor complications in … with rates of disease progression (UPDRS and b-CIT) and dyskinesia development. The results may provide important …
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Targeting the Dopamine D1 Receptor for a Treatment of Parkinson’s Disease with Minimal L-DOPA-induced Dyskinesia
… chronic administration induces abnormal movements termed dyskinesias. Dyskinesias are caused by imbalances in signaling via an … the retention of normal mobility without inducing dyskinesias in people with PD. Hypothesis: Our hypothesis …
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Functional Inhibition of RasGRF1 in the MPTP-lesioned NHP Model for Treating Levodopa-induced Dyskinesia
… Objective/Rationale: Levodopa-induced dyskinesias are caused by an increased and aberrant response … in the striatum, and hopefully decrease the severity of dyskinesias. Project Description: We aim at downregulating … Diagnosis/Treatment of Parkinson’s Disease: L-dopa-induced dyskinesia severely limits the usability of L-dopa, the most …
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Gene Expression Changes in Striatal Cholinergic Interneurons Associated with Levodopa-induced Dyskinesia
… part of the brain called the striatum in levodopa-induced dyskinesia. This small population of striatal neurons has … for PD. We will carry out a similar approach for PD and dyskinesia models. Hypothesis: We hypothesize that selective … changes in the striatal cholinergic neurons associated with dyskinesia, they will be targeted for therapy of dyskinesia. …
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Development of Functional Imaging for CB-1 and 5-HT1a in PD Participants with Dyskinesia
… receptors may play an important role in levodopa-induced dyskinesia. The development of imaging tests to evaluate the … the changes that occur in individuals with levodopa-induced dyskinesia and the potential to develop medications that more effectively treat dyskinesias. Project Description: Six PD subjects with …